Sugi Predict

Sugi Predict / Compounds / SCHEMBL4883526

SCHEMBL4883526

SCHEMBL4883526

Cc1ccc(S(=O)(=O)NN=CC(=O)Cl)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 10/20 0.55
▸ F2 P00734 1/20 0.53
▸ PRSS1 P07477 1/20 0.53
▸ PRSS2 P07478 1/20 0.53
▸ PRSS3 P35030 1/20 0.53
▸ KMT2A Q03164 9/20 0.51
▸ MEN1 O00255 7/20 0.51
▸ POLB P06746 4/20 0.51
▸ RECQL P46063 2/20 0.51
▸ L3MBTL1 Q9Y468 1/20 0.51
▸ KDM4E B2RXH2 1/20 0.50
▸ MAPT P10636 2/20 0.49
▸ RBM39 Q14498 1/20 0.49
▸ CA1 P00915 1/20 0.49
▸ CA2 P00918 1/20 0.49
▸ MMP1 P03956 1/20 0.49
▸ MMP2 P08253 1/20 0.49
▸ MMP9 P14780 1/20 0.49
▸ MMP8 P22894 1/20 0.49
▸ MMP13 P45452 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12749341 1.00 ALDH1A1 (0.55) ALDH1A1F2PRSS1PRSS2PRSS3
SCHEMBL3634237 0.85 ALDH1A1 (0.56) ALDH1A1F2PRSS1PRSS2PRSS3
SCHEMBL3634239 0.85 ALDH1A1 (0.56) ALDH1A1F2PRSS1PRSS2PRSS3
SCHEMBL23172046 0.80 ALDH1A1 (0.56) ALDH1A1F2PRSS1PRSS2PRSS3
SCHEMBL28615508 0.79 ALDH1A1 (0.56) ALDH1A1F2PRSS1PRSS2PRSS3
SCHEMBL30835597 0.79 ALDH1A1 (0.53) ALDH1A1F2PRSS1PRSS2PRSS3
SCHEMBL30835598 0.79 ALDH1A1 (0.53) ALDH1A1F2PRSS1PRSS2PRSS3
SCHEMBL12748381 0.78 ALDH1A1 (0.62) ALDH1A1F2PRSS1PRSS2PRSS3
SCHEMBL5279394 0.78 ALDH1A1 (0.62) ALDH1A1F2PRSS1PRSS2PRSS3
SCHEMBL10926045 0.78 ALDH1A1 (0.62) ALDH1A1F2PRSS1PRSS2PRSS3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4029868-B1 MCL-1 INHIBITORS GILEAD SCIENCES INC (US) 2026-05-20 — — EP disclosed
CN-117304130-A MCL-1 inhibitors 吉利德科学公司 2023-12-29 — — CN disclosed
US-20230312490-A1 MCL-1 INHIBITORS GILEAD SCIENCES, INC. 2023-10-05 — — US disclosed
CN-112118845-B MCL-1 inhibitors 吉利德科学公司 2023-06-13 — — CN disclosed
US-11643400-B2 MCL-1 inhibitors GILEAD SCIENCES, INC. (US) 2023-05-09 — — US disclosed
US-20220340535-A1 MCL-1 INHIBITORS GILEAD SCIENCES, INC. 2022-10-27 — — US disclosed
EP-4029868-A1 MCL-1 INHIBITORS GILEAD SCIENCES, INC. (US) 2022-07-20 — — EP disclosed
EP-3793565-B1 MCL-1 INHIBITORS GILEAD SCIENCES INC (US) 2022-01-05 — — EP disclosed
US-10988451-B2 MCL-1 inhibitors GILEAD SCIENCES, INC. (US) 2021-04-27 — — US disclosed
EP-3793565-A1 MCL-1 INHIBITORS Gilead Sciences, Inc. (US) 2021-03-24 — — EP disclosed
CN-112118845-A MCL-1 inhibitors 吉利德科学公司 2020-12-22 — — CN disclosed
US-20200331870-A1 MCL-1 INHIBITORS GILEAD SCIENCES, INC. 2020-10-22 — — US disclosed
US-10703733-B2 MCL-1 inhibitors GILEAD SCIENCES, INC. (US) 2020-07-07 — — US disclosed
US-20190352271-A1 MCL-1 INHIBITORS GILEAD SCIENCES, INC. 2019-11-21 — — US disclosed
EP-1386158-B1 OBJECT COMPRISING AN UNCHARGED, FUNCTIONALIZED HYDROGEL SURFACE HOFMANN ANDREAS (DE) 2008-05-14 — — EP disclosed
US-20080090884-A1 ANTIMICROBIAL [3.1.0] BICYCLOHEXYLPHENYL- OXAZOLIDINONE DERIVATIVES AND ANALOGUES PFIZER INC 2008-04-17 — — US disclosed
US-7279494-B2 Antimicrobial [3.1.0] bicyclohexylphenyl-oxazolidinone derivatives and analogues PFIZER INC. (US) 2007-10-09 — — US disclosed
US-20050192325-A1 Antimicrobial [3.1.0] bicyclohexylphenyl-oxazolidinone derivatives and analogues RENSLO ADAM (US) 2005-09-01 — — US disclosed
US-20040157149-A1 Object comprising an uncharged, functionalized hydrogel surface HOFMANN, ANDREAS (DE) 2004-08-12 — — US disclosed
WO-1992000972-A1 RENIN INHIBITING COMPOUNDS ABBOTT LABORATORIES (US) 1992-01-23 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190352271-A1 MCL-1 INHIBITORS MCL1, BCL2L1, BCL2 ALDH1A1 1991/4885F2 4728/4885PRSS1 2876/4885
US-20200331870-A1 MCL-1 INHIBITORS MCL1, BCL2L1, BCL2 ALDH1A1 1991/4885F2 4728/4885PRSS1 2876/4885
US-20230312490-A1 MCL-1 INHIBITORS MCL1, BCL2L1, BCL2 ALDH1A1 1991/4885F2 4728/4885PRSS1 2876/4885
US-10703733-B2 MCL-1 inhibitors MCL1, BCL2L1, BCL2 ALDH1A1 1991/4885F2 4728/4885PRSS1 2876/4885
US-11643400-B2 MCL-1 inhibitors MCL1, BCL2L1, BCL2 ALDH1A1 1991/4885F2 4728/4885PRSS1 2876/4885
US-20050192325-A1 Antimicrobial [3.1.0] bicyclohexylphenyl-oxazolidinone derivatives and analogues OXA1L, CYP51A1, CYP2C19 ALDH1A1 403/4885F2 2080/4885PRSS1 2611/4885
US-20080090884-A1 ANTIMICROBIAL [3.1.0] BICYCLOHEXYLPHENYL- OXAZOLIDINONE DERIVATIVES AND ANALOGUES OXA1L, CYP51A1, CYP2C19 ALDH1A1 369/4885F2 2087/4885PRSS1 2565/4885
US-10988451-B2 MCL-1 inhibitors MCL1, BCL2L1, BCL2 ALDH1A1 1991/4885F2 4728/4885PRSS1 2876/4885
US-20220340535-A1 MCL-1 INHIBITORS MCL1, BCL2L1, BCL2 ALDH1A1 1991/4885F2 4728/4885PRSS1 2876/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.