Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.66 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | BTK | Q06187 | 1/20 | 0.53 |
| ▸ | BRAF | P15056 | 4/20 | 0.51 |
| ▸ | RAF1 | P04049 | 3/20 | 0.49 |
| ▸ | TEK | Q02763 | 2/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | BCR | P11274 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | PLG | P00747 | 1/20 | 0.49 |
| ▸ | PLAU | P00749 | 1/20 | 0.49 |
| ▸ | PLAT | P00750 | 1/20 | 0.49 |
| ▸ | YES1 | P07947 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4881020 | 0.89 | MAPK14 (0.59) | MAPK14LCKBRAFRAF1TEK | |
| SCHEMBL4884245 | 0.89 | MAPK14 (0.53) | MAPK14LCKBTKBRAFRAF1 | |
| SCHEMBL4877990 | 0.88 | MAPK14 (0.58) | MAPK14LCKBRAFRAF1TEK | |
| SCHEMBL5504832 | 0.88 | MAPK14 (0.57) | MAPK14LCKBTKBRAFTEK | |
| SCHEMBL4878817 | 0.83 | MAPK14 (0.53) | MAPK14LCKBTKBRAFTEK | |
| SCHEMBL4890582 | 0.83 | MAPK14 (0.78) | MAPK14BRAFRAF1 | |
| SCHEMBL4884817 | 0.80 | TEK (0.53) | MAPK14LCKBTKBRAFRAF1 | |
| SCHEMBL27682252 | 0.79 | AURKA (0.56) | MAPK14LCKBTKBRAFRAF1 | |
| SCHEMBL4882125 | 0.78 | MAPK14 (0.69) | MAPK14BRAFRAF1 | |
| SCHEMBL4881183 | 0.78 | BRAF (0.57) | MAPK14BRAFRAF1YES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080275022-A1 | Substituted Quinazolones as Anti-Cancer Agents | ASTRAZENECA AB (SE) | 2008-11-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275022-A1 | Substituted Quinazolones as Anti-Cancer Agents | BRAF, NRAS, RAF1 | MAPK14 153/4885LCK 228/4885BTK 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.