Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.57 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.55 |
| ▸ | BRAF | P15056 | 6/20 | 0.55 |
| ▸ | ABL1 | P00519 | 2/20 | 0.53 |
| ▸ | BCR | P11274 | 1/20 | 0.53 |
| ▸ | TEK | Q02763 | 3/20 | 0.53 |
| ▸ | KIT | P10721 | 2/20 | 0.52 |
| ▸ | LCK | P06239 | 2/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | CSF1R | P07333 | 1/20 | 0.52 |
| ▸ | BTK | Q06187 | 1/20 | 0.52 |
| ▸ | FES | P07332 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
| ▸ | FLT1 | P17948 | 1/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.51 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4881020 | 0.90 | MAPK14 (0.59) | MAPK14EPHB4BRAFABL1BCR | |
| SCHEMBL4878817 | 0.90 | MAPK14 (0.53) | MAPK14EPHB4BRAFABL1BCR | |
| SCHEMBL4877990 | 0.90 | MAPK14 (0.58) | MAPK14EPHB4BRAFABL1BCR | |
| SCHEMBL4884285 | 0.88 | MAPK14 (0.66) | MAPK14BRAFABL1BCRTEK | |
| SCHEMBL4831532 | 0.88 | MAPK14 (0.70) | MAPK14 | |
| SCHEMBL4884817 | 0.86 | TEK (0.53) | MAPK14EPHB4BRAFABL1BCR | |
| SCHEMBL27682252 | 0.85 | AURKA (0.56) | MAPK14EPHB4BRAFABL1BCR | |
| SCHEMBL4890582 | 0.84 | MAPK14 (0.78) | MAPK14BRAF | |
| SCHEMBL4882125 | 0.84 | MAPK14 (0.69) | MAPK14BRAF | |
| SCHEMBL4884245 | 0.83 | MAPK14 (0.53) | MAPK14BRAFABL1BCRTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1789400-A1 | QUINAZOLINONE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS | AstraZeneca AB (SE) | 2007-05-30 | — | — | EP | claimed |
| WO-2006024836-A1 | QUINAZOLINONE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS | ASTRAZENECA AB (SE) | 2006-03-09 | — | — | WO | claimed |