Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ceftriaxone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 6/20 | 0.79 |
| ▸ | PGR | P06401 | 3/20 | 0.79 |
| ▸ | PPARG | P37231 | 2/20 | 0.79 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.79 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 0.79 |
| ▸ | SLC22A11 | Q9NSA0 | 2/20 | 0.79 |
| ▸ | DAO | P14920 | 1/20 | 0.79 |
| ▸ | SNCA | P37840 | 1/20 | 0.79 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.79 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.78 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.77 |
| ▸ | MAPT | P10636 | 5/20 | 0.77 |
| ▸ | APEX1 | P27695 | 3/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.77 |
| ▸ | POLB | P06746 | 2/20 | 0.77 |
| ▸ | RECQL | P46063 | 2/20 | 0.77 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.77 |
| ▸ | BLM | P54132 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ceftriaxone SCHEMBL8378294 | 0.99 | NR1I2 (0.80) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL2224183 | 0.99 | NR1I2 (0.80) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL2006477 | 0.99 | NR1I2 (0.80) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL4897101 | 0.99 | NR1I2 (0.80) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL30307091 | 0.99 | NR1I2 (0.80) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL8619948 | 0.99 | NR1I2 (0.80) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL2006478 | 0.99 | NR1I2 (0.80) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL23354 | 0.99 | NR1I2 (0.80) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL22635993 | 0.99 | NR1I2 (0.79) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL150106 | 0.99 | NR1I2 (0.79) | NR1I2PGRPPARGSLC22A6SLC22A8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470786-B2 | Method for manufacture of ceftriaxone sodium | LUPIN LIMITED (IN) | 2008-12-30 | — | — | US | disclosed |
| US-20080200670-A1 | METHOD FOR THE MANUFACTURE OF CEFTRIAXONE SODIUM | LUPIN LIMITED (RESEARCH PARK) (IN) | 2008-08-21 | — | — | US | disclosed |
| US-20070049749-A1 | Method for Manufacture of Ceftriaxone Sodium | LUPIN LIMITED (RESEARCH PARK) (IN) | 2007-03-01 | — | — | US | disclosed |
| US-20070015917-A1 | Method For Manufacture of Ceftriaxone Sodium | LUPIN LIMITED (RESEARCH PARK) (IN) | 2007-01-18 | — | — | US | disclosed |
| US-20050059821-A1 | Method for manufacture of ceftriaxone sodium | DATTA DEBASHISH (IN) | 2005-03-17 | — | — | US | disclosed |
| US-20050059820-A1 | Method for manufacture of ceftriaxone sodium | LUPIN LIMITED (IN) | 2005-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070049749-A1 | Method for Manufacture of Ceftriaxone Sodium | TREH, CHAT, MRPL21 | NR1I2 3329/4885PGR 4786/4885PPARG 4059/4885 |
| US-20050059820-A1 | Method for manufacture of ceftriaxone sodium | TREH, CHAT, MRPL21 | NR1I2 3329/4885PGR 4786/4885PPARG 4059/4885 |
| US-20070015917-A1 | Method For Manufacture of Ceftriaxone Sodium | TREH, CHAT, MRPL21 | NR1I2 3329/4885PGR 4786/4885PPARG 4059/4885 |
| US-20080200670-A1 | METHOD FOR THE MANUFACTURE OF CEFTRIAXONE SODIUM | CHAT, TREH, MRPL21 | NR1I2 3205/4885PGR 4730/4885PPARG 4167/4885 |
| US-20050059821-A1 | Method for manufacture of ceftriaxone sodium | TREH, CHAT, MRPL21 | NR1I2 3329/4885PGR 4786/4885PPARG 4059/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.