TREH

Trehalase · O43280 · TREH on Sugi Atlas →

601 patent compounds predicted against TREH, 370 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Duvoglustat (SCHEMBL2969)	1.00	1/20
Duvoglustat (SCHEMBL142573)	1.00	1/20
Deoxymannojirimycin (SCHEMBL329674)	1.00	1/20
Duvoglustat (SCHEMBL1479364)	1.00	1/20
Duvoglustat (SCHEMBL1527007)	1.00	1/20
Duvoglustat (SCHEMBL1527009)	1.00	1/20
Duvoglustat (SCHEMBL2163281)	1.00	1/20
Duvoglustat (SCHEMBL2434068)	1.00	1/20
Deoxymannojirimycin (SCHEMBL3367857)	1.00	1/20
Deoxymannojirimycin (SCHEMBL4323978)	1.00	1/20
Duvoglustat (SCHEMBL4330678)	1.00	1/20
Salbostatin (SCHEMBL4369501)	1.00	1/20
Duvoglustat (SCHEMBL4619759)	1.00	1/20
Duvoglustat (SCHEMBL8010302)	1.00	1/20
Duvoglustat (SCHEMBL9015606)	1.00	1/20
Duvoglustat (SCHEMBL9290667)	1.00	1/20
Duvoglustat (SCHEMBL9620329)	1.00	1/20
Duvoglustat (SCHEMBL9620331)	1.00	1/20
Duvoglustat (SCHEMBL10028910)	1.00	1/20
Duvoglustat (SCHEMBL12017698)	1.00	1/20

Clinical trials — most relevant to TREH by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Efficacy and Tolerability of α-galactosidase in Treating Gas-related Symptoms in Children	PHASE4	COMPLETED
European Trial Into Mpox Infection	PHASE4	RECRUITING
HEALEY ALS Platform Trial - Regimen E SLS-005 - Trehalose	PHASE2/PHASE3	COMPLETED
The Role of SGLT2i in Management of Moderate AS	PHASE2/PHASE3	UNKNOWN
Treatment of Oculopharyngeal Muscular Dystrophy With Trehalose	PHASE2	WITHDRAWN
A Double-Blind, Placebo-Controlled Study of Fermented Deglycyrrhizinated Licorice Extract	PHASE2	COMPLETED
Vaccine Treatment for Advanced Non-Small Cell Lung Cancer	PHASE1/PHASE2	COMPLETED
A Phase I Study of Pyrimethamine in Patients With GM2 Gangliosidosis	PHASE1	WITHDRAWN
A Study of the Enzyme Activity and Safety of Pancrelipase in Patients With Severe Exocrine Pancreatic Insufficiency (EPI)	PHASE1	COMPLETED
Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction	EARLY_PHASE1	RECRUITING
Early Diagnosis of Acute Renal Failure by Urine Trehalase Levels.	nan	NOT_YET_RECRUITING
Clinical Effects of Oral Trehalose In Patients With Spinocerebellar Ataxia 3	nan	COMPLETED
Trehalose Administration in Subjects With Spastic Paraplegia 11 (3AL-SPG11)	nan	COMPLETED
Acute Pancreatitis Targets (APT) Study	nan	COMPLETED
Evaluation of Gastrointestinal Symptoms Following Chilean Native Beans Consumption	nan	UNKNOWN
Efficacy Of Oral Trehalose In Spinocerebellar Ataxia 3	nan	UNKNOWN
Lyso-Gb1 as a Long-term Prognostic Biomarker in Gaucher Disease	nan	COMPLETED
ProGRP, CgA, NSE and TUM2-PK in in Patients With Neuroendocrine Tumors	nan	UNKNOWN
Effects of Preoperative Oral Carbohydrate Loading on Maternal Thiol-disulfide Homeostasis	nan	COMPLETED
Registry Gangliosidoses	nan	UNKNOWN
Trehalose in Subjects With Neuronal Ceroid Lipofuscinoses	nan	COMPLETED
Extra Virgin Olive Oil on Glycemic Control ,Insulin Resistance and Insulin Secretion	nan	UNKNOWN
Screening of Lysosomal Storage Disorders Diseases in Minority Groups	nan	UNKNOWN
Efficacy of Fructose Metabolizing Enzymatic Product in Fructose Malabsorption	nan	COMPLETED
Detection of Pompe Disease in Adult Patients With Myopathies of Uncertain Origin or With Asymptomatic Hyper-CK-emia	nan	UNKNOWN
Intermediate-Sized Expanded Access Study	nan	NO_LONGER_AVAILABLE
A Study to Evaluate and Characterize the Effect of Pharmacological Chemicals on Blood From Patients With Gaucher Disease	nan	COMPLETED
Breath Test-Based Assessment of SIBO in Chronic Pancreatitis and Partial Pancreatectomy	nan	NOT_YET_RECRUITING
SRT in Comparison to ERT on Immune Aspects and Bone Involvement in Gaucher Disease	nan	UNKNOWN
Comparison of the Effectiveness of Oral Lactase Enzyme and Lactose Free Formula	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a TREH binder may also engage these)

Protein	Name	Similarity
P19813	—	1.000	P19813 →
Q9JLT2	—	0.998	Q9JLT2 →
Q13724	—	0.982	Q13724 →
O88941	—	0.980	O88941 →
GAA	Lysosomal alpha-glucosidase	0.979	landscape →
A0JMP0	—	0.978	A0JMP0 →
Q80UM7	—	0.976	Q80UM7 →
P0DPE2	—	0.975	P0DPE2 →
P70699	—	0.974	P70699 →
Q3U4H6	—	0.973	Q3U4H6 →
HEXD	Hexosaminidase D	0.973	landscape →
ITGB7	Integrin beta-7	0.972	landscape →
Q91ZJ9	—	0.972	Q91ZJ9 →
Q8VDP3	—	0.972	Q8VDP3 →
Q3SZM7	—	0.972	Q3SZM7 →
O35632	—	0.972	O35632 →
Q9MYM4	—	0.972	Q9MYM4 →
P0DPD8	—	0.971	P0DPD8 →
Q76HN1	—	0.971	Q76HN1 →
TARS2	Threonine--tRNA ligase, mitochondrial	0.971	landscape →
FUCA1	Tissue alpha-L-fucosidase	0.971	landscape →
Q6RHW4	—	0.971	Q6RHW4 →
Q5R5N6	—	0.971	Q5R5N6 →
Q5FVF9	—	0.971	Q5FVF9 →
Q8R123	—	0.971	Q8R123 →
P17164	—	0.971	P17164 →
P26011	—	0.970	P26011 →
Q60HF8	—	0.970	Q60HF8 →
Q7M758	—	0.970	Q7M758 →
P09849	—	0.970	P09849 →