Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 14/20 | 0.41 |
| ▸ | NOS3 | P29474 | 4/20 | 0.38 |
| ▸ | NOS1 | P29475 | 4/20 | 0.38 |
| ▸ | NOS2 | P35228 | 3/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8257710 | 1.00 | NAMPT (0.41) | NAMPTNOS3NOS1NOS2HDAC8 | |
| SCHEMBL4885312 | 1.00 | NAMPT (0.41) | NAMPTNOS3NOS1NOS2HDAC8 | |
| SCHEMBL4884658 | 0.82 | TAS1R3 (0.47) | NAMPTNOS3NOS1NOS2 | |
| SCHEMBL4884664 | 0.82 | TAS1R3 (0.47) | NAMPTNOS3NOS1NOS2 | |
| SCHEMBL8259700 | 0.82 | TAS1R3 (0.47) | NAMPTNOS3NOS1NOS2 | |
| SCHEMBL4880755 | 0.72 | SMN1; SMN2 (0.52) | NAMPT | |
| SCHEMBL4881917 | 0.71 | DPP8 (0.40) | NAMPTNOS3NOS1NOS2 | |
| SCHEMBL4881919 | 0.71 | DPP8 (0.40) | NAMPTNOS3NOS1NOS2 | |
| SCHEMBL14066260 | 0.71 | DPP8 (0.40) | NAMPTNOS3NOS1NOS2 | |
| SCHEMBL12660102 | 0.70 | NOTUM (0.56) | NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234252-A1 | Compounds Useful in Therapy | PFIZER INC | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234252-A1 | Compounds Useful in Therapy | AVPR1A, AVPR1B, AVPR2 | NAMPT 4061/4885NOS3 1527/4885NOS1 2189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.