Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PLA2G4A | P47712 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4883341 | 0.78 | KMT2A (0.43) | SLC22A12KDM4EHTTALDH1A1HPGD | |
| SCHEMBL4882576 | 0.71 | S1PR3 (0.61) | — | |
| SCHEMBL8603362 | 0.70 | SLC22A12 (0.51) | KDM4CSLC22A12KDM4EPLA2G4AALDH1A1 | |
| Hydrochloric Acid SCHEMBL8602145 | 0.69 | SLC22A12 (0.50) | KDM4CSLC22A12KDM4EPLA2G4AALDH1A1 | |
| SCHEMBL2482006 | 0.65 | KDM4E (0.56) | SLC22A12KDM4EHTTALDH1A1HPGD | |
| SCHEMBL4885356 | 0.64 | S1PR3 (0.42) | KDM4EALDH1A1POLB | |
| SCHEMBL1552943 | 0.64 | SLC22A12 (0.49) | KDM4CSLC22A12KDM4EPLA2G4AALDH1A1 | |
| Hydrochloric Acid SCHEMBL8605198 | 0.63 | SLC22A12 (0.48) | KDM4CSLC22A12KDM4EPLA2G4AALDH1A1 | |
| SCHEMBL6377411 | 0.62 | ALDH1A1 (0.40) | SLC22A12KDM4EALDH1A1POLBL3MBTL1 | |
| SCHEMBL13011133 | 0.61 | ALDH1A1 (0.46) | SLC22A12KDM4EHTTPLA2G4AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8524917-B2 | 6-substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity | ALLERGAN, INC. (US) | 2013-09-03 | — | — | US | disclosed |
| US-20080171772-A1 | e.g. Methyl 1-Benzyl-6-methoxy-1H-indole-2-carboxylate; glaucoma, dry eye, angiogenesis, cardiovascular conditions and diseases, wound healing, platelet aggregation and thrombosis | ALLERGAN, INC. | 2008-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080171772-A1 | e.g. Methyl 1-Benzyl-6-methoxy-1H-indole-2-carboxylate; glaucoma, dry eye, angiogenesis, cardiovascular conditions and diseases, wound healing, platelet aggregation and thrombosis | PTGIR, S1PR1, TBXA2R | KDM4C 1914/4885SLC22A12 4258/4885KDM4E 1436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.