Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 13/20 | 0.68 |
| ▸ | BTK | Q06187 | 1/20 | 0.53 |
| ▸ | SYK | P43405 | 1/20 | 0.51 |
| ▸ | CDK4 | P11802 | 1/20 | 0.49 |
| ▸ | CCND1 | P24385 | 1/20 | 0.49 |
| ▸ | CCND2 | P30279 | 1/20 | 0.49 |
| ▸ | CCND3 | P30281 | 1/20 | 0.49 |
| ▸ | INSR | P06213 | 2/20 | 0.48 |
| ▸ | KIT | P10721 | 2/20 | 0.48 |
| ▸ | SRC | P12931 | 2/20 | 0.48 |
| ▸ | FLT3 | P36888 | 2/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | BRD4 | O60885 | 2/20 | 0.45 |
| ▸ | WEE1 | P30291 | 1/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | MARK3 | P27448 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4891439 | 0.99 | CSF1R (0.69) | CSF1RBTKSYKCDK4CCND1 | |
| SCHEMBL4884345 | 0.91 | CSF1R (0.81) | CSF1RCDK4INSRKITSRC | |
| SCHEMBL4573218 | 0.90 | CSF1R (0.84) | CSF1RBTKSYKCDK4CCND1 | |
| SCHEMBL4573725 | 0.89 | CSF1R (0.86) | CSF1RBTKSYKCDK4CCND1 | |
| SCHEMBL4583669 | 0.88 | CSF1R (0.72) | CSF1RBTKSYKCDK4CCND1 | |
| SCHEMBL4574257 | 0.88 | CSF1R (0.74) | CSF1RBTKSYKCDK4CCND1 | |
| SCHEMBL4882338 | 0.84 | CSF1R (0.82) | CSF1RINSRKITSRCFLT3 | |
| SCHEMBL14196179 | 0.83 | CSF1R (0.82) | CSF1RINSRKITSRCFLT3 | |
| SCHEMBL4891427 | 0.83 | CSF1R (0.60) | CSF1RSYKCDK4CCND1CCND2 | |
| SCHEMBL4889961 | 0.82 | CSF1R (0.60) | CSF1RCDK4CCND1CCND2CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080114007-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080114007-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | FLT3, FES, ALK | CSF1R 430/4885BTK 234/4885SYK 43/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.