Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 8/20 | 0.60 |
| ▸ | AURKA | O14965 | 2/20 | 0.45 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 7/20 | 0.44 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.44 |
| ▸ | CCND1 | P24385 | 5/20 | 0.43 |
| ▸ | CCND3 | P30281 | 5/20 | 0.43 |
| ▸ | CCND2 | P30279 | 2/20 | 0.43 |
| ▸ | CDK1 | P06493 | 4/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.43 |
| ▸ | CDK2 | P24941 | 3/20 | 0.43 |
| ▸ | CDK9 | P50750 | 3/20 | 0.43 |
| ▸ | CDK3 | Q00526 | 2/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | WEE1 | P30291 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4891427 | 0.99 | CSF1R (0.60) | CSF1RAURKACAMK2DCDK4CDK6 | |
| SCHEMBL4572809 | 0.88 | CSF1R (0.74) | CSF1RCAMK2D | |
| SCHEMBL4588365 | 0.88 | CSF1R (0.73) | CSF1RCAMK2D | |
| SCHEMBL4763203 | 0.84 | CSF1R (0.62) | CSF1RAURKACDK4CCND1CCND3 | |
| SCHEMBL4882532 | 0.84 | CSF1R (0.80) | CSF1RCAMK2D | |
| SCHEMBL4891439 | 0.83 | CSF1R (0.69) | CSF1RCDK4CCND1CCND3CCND2 | |
| SCHEMBL4884345 | 0.83 | CSF1R (0.81) | CSF1RAURKACDK4CDK1WEE1 | |
| SCHEMBL4885406 | 0.83 | CSF1R (0.79) | CSF1RCAMK2D | |
| SCHEMBL4767401 | 0.83 | CSF1R (0.86) | CSF1RAURKACDK4CDK6CCND1 | |
| SCHEMBL4885531 | 0.82 | CSF1R (0.68) | CSF1RCDK4CCND1CCND3CCND2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080114007-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080114007-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | FLT3, FES, ALK | CSF1R 430/4885AURKA 19/4885CAMK2D 712/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.