Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SELE | P16581 | 6/20 | 0.51 |
| ▸ | ICAM1 | P05362 | 5/20 | 0.51 |
| ▸ | VCAM1 | P19320 | 4/20 | 0.51 |
| ▸ | TMIGD3 | P0DMS9 | 2/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CDK8 | P49336 | 4/20 | 0.34 |
| ▸ | CCNC | P24863 | 3/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.34 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23093512 | 0.76 | ICAM1 (0.57) | SELEICAM1VCAM1CDK8CCNC | |
| SCHEMBL30744177 | 0.76 | ICAM1 (0.57) | SELEICAM1VCAM1CDK8CCNC | |
| SCHEMBL5333499 | 0.76 | ICAM1 (0.53) | SELEICAM1VCAM1CDK8CCNC | |
| SCHEMBL3708981 | 0.75 | ICAM1 (0.56) | SELEICAM1VCAM1CDK8CCNC | |
| SCHEMBL20659865 | 0.74 | SELE (0.46) | SELEICAM1VCAM1TMIGD3ADORA1 | |
| SCHEMBL20659879 | 0.71 | ICAM1 (0.49) | SELEICAM1VCAM1CDK8PIM1 | |
| SCHEMBL23109949 | 0.71 | ICAM1 (0.49) | SELEICAM1VCAM1CYP2C9CDK8 | |
| SCHEMBL7058858 | 0.68 | ICAM1 (1.00) | SELEICAM1VCAM1 | |
| SCHEMBL24845323 | 0.68 | ICAM1 (0.45) | SELEICAM1VCAM1CDK8CCNC | |
| SCHEMBL23522277 | 0.68 | ICAM1 (0.53) | SELEICAM1VCAM1CDK8CCNC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019018359-A1 | THIENO[2,3-D)PYRIMIDINES AND BENZOFURO(3,2-D)PYRIMIDINES AS ANTIMICROBIAL AGENTS | SAINT LOUIS UNIVERSITY (US) | 2019-01-24 | — | — | WO | disclosed |
| US-7384949-B2 | Thieno(3,2-d)pyrimidines and furano(3,2-d)pyrimidines and their use as purinergic receptor antagonists | VERNALIS RESEARCH LIMITED (GB) | 2008-06-10 | — | — | US | disclosed |
| US-20040097524-A1 | Thieno(3,2-d)pyrimidines and furano(3,2-d)pyimidines and their use as purinergic receptor antagonists | VERNALIS RESEARCH LIMITED (GB) | 2004-05-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040097524-A1 | Thieno(3,2-d)pyrimidines and furano(3,2-d)pyimidines and their use as purinergic receptor antagonists | CNR1, CNR2, RYR2 | SELE 4075/4885ICAM1 4484/4885VCAM1 3536/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.