Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Rivoglitazone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG known ✓ | P37231 | 10/20 | 0.91 |
| ▸ | FFAR1 | O14842 | 10/20 | 0.68 |
| ▸ | PPARA | Q07869 | 5/20 | 0.68 |
| ▸ | ESRRA | P11474 | 1/20 | 0.68 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | MPC2 | O95563 | 1/20 | 0.52 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rivoglitazone SCHEMBL5319250 | 0.96 | PPARG (1.00) | PPARGFFAR1PPARAESRRAMPC2 | |
| Rivoglitazone SCHEMBL143498 | 0.96 | PPARG (1.00) | PPARGFFAR1PPARAESRRAMPC2 | |
| Rivoglitazone SCHEMBL2906120 | 0.96 | PPARG (1.00) | PPARGFFAR1PPARAESRRAMPC2 | |
| Rivoglitazone SCHEMBL1592290 | 0.95 | PPARG (0.98) | PPARGFFAR1PPARAESRRAMPC2 | |
| Rivoglitazone SCHEMBL6064788 | 0.95 | PPARG (0.98) | PPARGFFAR1PPARAESRRAMPC2 | |
| SCHEMBL1130955 | 0.93 | PPARG (0.79) | PPARGFFAR1PPARAESRRANPC1 | |
| SCHEMBL6543624 | 0.90 | PPARG (0.90) | PPARGFFAR1PPARAESRRAMPC2 | |
| SCHEMBL6896700 | 0.90 | PPARG (0.86) | PPARGFFAR1PPARAESRRAMPC2 | |
| Hydrochloric Acid SCHEMBL6544473 | 0.90 | PPARG (0.88) | PPARGFFAR1PPARAESRRAMPC2 | |
| SCHEMBL7241913 | 0.90 | PPARG (0.82) | PPARGFFAR1PPARAESRRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021210-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | COMBINATORX, INCORPORATED (US) | 2008-02-21 | — | — | WO | disclosed |