Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.51 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4897800 | 0.86 | HDAC1 (0.57) | SMN1; SMN2L3MBTL1LMNAHTTHDAC1 | |
| SCHEMBL24890971 | 0.73 | HDAC2 (0.58) | SMN1; SMN2L3MBTL1LMNAHTTHDAC1 | |
| SCHEMBL8268262 | 0.73 | ABCB1 (0.58) | SMN1; SMN2L3MBTL1LMNAHTTHDAC1 | |
| SCHEMBL1064790 | 0.72 | HDAC1 (0.60) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL8269800 | 0.72 | HDAC1 (0.50) | L3MBTL1HDAC1HDAC2ABCB1ABCG2 | |
| SCHEMBL4261230 | 0.72 | HDAC2 (0.54) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL4261233 | 0.72 | HDAC2 (0.54) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL8401704 | 0.71 | HDAC1 (0.89) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL5159210 | 0.70 | SMN1; SMN2 (0.72) | SMN1; SMN2LMNAMEN1KMT2AABCB1 | |
| SCHEMBL12226492 | 0.70 | MEN1 (0.61) | L3MBTL1HDAC1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234254-A1 | Inhibitors of Histone Deacetylase | UNIVERSITY OF LEEDS (GB) | 2008-09-25 | — | — | US | disclosed |
| US-20080234254-A1 | Inhibitors of Histone Deacetylase | UNIVERSITY OF LEEDS (GB) | 2008-09-25 | — | — | US | disclosed |
| US-20080234254-A1 | Inhibitors of Histone Deacetylase | UNIVERSITY OF LEEDS (GB) | 2008-09-25 | — | — | US | disclosed |
| EP-1758847-A1 | INHIBITORS OF HISTONE DEACETYLASE | Cancer Research Technology Limited (GB) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005121073-A1 | INHIBITORS OF HISTONE DEACETYLASE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2005-12-22 | — | — | WO | disclosed |
| WO-2005121073-A1 | INHIBITORS OF HISTONE DEACETYLASE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2005-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234254-A1 | Inhibitors of Histone Deacetylase | HDAC8, HDAC4, HDAC5 | SMN1; SMN2 4631/4885L3MBTL1 1355/4885LMNA 883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.