Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 18/20 | 0.59 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.48 |
| ▸ | MARK3 | P27448 | 2/20 | 0.48 |
| ▸ | AKT1 | P31749 | 2/20 | 0.48 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.47 |
| ▸ | PIM1 | P11309 | 3/20 | 0.47 |
| ▸ | GSK3A | P49840 | 3/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.47 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.47 |
| ▸ | CDK1 | P06493 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.47 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4855660 | 0.85 | CHEK1 (0.55) | CHEK1AURKBCHEK2MARK3AKT1 | |
| SCHEMBL4885501 | 0.82 | CHEK1 (0.59) | CHEK1AURKBCHEK2MARK3AKT1 | |
| SCHEMBL4888106 | 0.82 | CASP3 (0.60) | CHEK1CASP3PRKAA1 | |
| SCHEMBL4891071 | 0.79 | CASP3 (0.56) | CHEK1CASP3PRKAA1KDRPDGFRB | |
| SCHEMBL4883779 | 0.79 | CHEK1 (0.66) | CHEK1 | |
| SCHEMBL4859402 | 0.79 | CHEK1 (0.66) | CHEK1AURKBCHEK2MARK3AKT1 | |
| SCHEMBL4854166 | 0.78 | CHEK1 (0.65) | CHEK1 | |
| SCHEMBL4859674 | 0.78 | CHEK1 (0.66) | CHEK1AURKBCHEK2MARK3AKT1 | |
| SCHEMBL4888658 | 0.77 | CHEK1 (0.66) | CHEK1 | |
| SCHEMBL4854940 | 0.76 | CHEK1 (0.67) | CHEK1AURKBCHEK2MARK3AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606268-B1 | 5,10-DIHYDRO-11H-DIBENZO[B,E][1,4]DIAZEPIN-11-ONE AS KINASE INHIBITORS | ABBVIE INC (US) | 2015-05-20 | — | — | EP | disclosed |
| US-7456169-B2 | Heterocyclic kinase inhibitors | ABBOTT LABORATORIES INC. (US) | 2008-11-25 | — | — | US | disclosed |
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | ABBVIE INC. | 2007-11-01 | — | — | US | disclosed |
| US-20040254159-A1 | Heterocyclic kinase inhibitors | ABBOTT LABORATORIES | 2004-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040254159-A1 | Heterocyclic kinase inhibitors | MAP3K20, MAP3K19, MAP3K1 | CHEK1 46/4885CASP3 2802/4885AURKB 196/4885 |
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | MAP3K20, MAP3K19, MAP4K2 | CHEK1 38/4885CASP3 2513/4885AURKB 165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.