Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR2 | P37173 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 4/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.45 |
| ▸ | ACVR2A | P27037 | 2/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 3/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4333317 | 0.84 | MAPT (0.57) | TGFBR2MAPTSMN1; SMN2LMNAPOLB | |
| SCHEMBL4332306 | 0.83 | TGFBR2 (0.54) | TGFBR2MAPTSMN1; SMN2LMNAPOLB | |
| SCHEMBL1424073 | 0.81 | MAPT (0.74) | TGFBR2MAPTSMN1; SMN2LMNAPOLB | |
| SCHEMBL102997 | 0.74 | PIM1 (0.61) | TGFBR2MAPTSMN1; SMN2LMNAPOLB | |
| SCHEMBL4883078 | 0.72 | PIK3CG (0.65) | TGFBR2PIK3CGFLT3PIM1PIM2 | |
| SCHEMBL4333206 | 0.72 | PIK3CG (0.65) | TGFBR2PIK3CGFLT3PIM1PIM2 | |
| SCHEMBL14302625 | 0.71 | FYN (0.58) | TGFBR2FYNPIK3CGACVR2ATGFBR1 | |
| SCHEMBL3634918 | 0.71 | MAPT (0.59) | TGFBR2MAPTSMN1; SMN2LMNAPOLB | |
| SCHEMBL14357041 | 0.70 | FYN (0.72) | TGFBR2FYNPIK3CGACVR2ATGFBR1 | |
| SCHEMBL17830895 | 0.70 | SCN5A (0.47) | FLT3PIK3CACDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080039455-A1 | PYRAZOLOPYRIMIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2008-02-14 | — | — | US | disclosed |
| WO-2007147647-A1 | PYRAZOLOPYRIMIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME. | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2007-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039455-A1 | PYRAZOLOPYRIMIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME | DPYD, FLT1, PDXK | TGFBR2 2444/4885MAPT 2762/4885SMN1; SMN2 2925/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.