Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fluoride Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9645205 | 0.94 | — | — | |
| SCHEMBL714228 | 0.94 | — | — | |
| Magnesium SCHEMBL7983993 | 0.91 | — | — | |
| SCHEMBL27689204 | 0.77 | — | — | |
| SCHEMBL254444 | 0.73 | CA1 (0.33) | — | |
| SCHEMBL11793529 | 0.70 | CA1 (0.31) | — | |
| SCHEMBL677858 | 0.70 | CA1 (0.31) | — | |
| SCHEMBL1263329 | 0.70 | CA1 (0.31) | — | |
| SCHEMBL6518481 | 0.70 | CA1 (0.31) | — | |
| SCHEMBL21049480 | 0.70 | CA1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080213400-A1 | Combinations of Chromium with Antidiabetics for Glucose Metabolism Disorders | AKESIS PHARMACEUTICALS (US) | 2008-09-04 | — | — | US | disclosed |
| US-20080181970-A1 | Combinations of Vanadium with Antidiabetics for Glucose Metabolism Disorders | AKESIS PHARMACEUTICALS (US) | 2008-07-31 | — | — | US | disclosed |
| US-20070293566-A1 | Combinations of vanadium with antidiabetics for glucose metabolism disorders | AKESIS PHARMACEUTICALS (US) | 2007-12-20 | — | — | US | disclosed |
| US-20070281042-A1 | Combinations of chromium with antidiabetics for glucose metabolism disorders | AKESIS PHARMACEUTICALS (US) | 2007-12-06 | — | — | US | disclosed |
| US-20070207218-A1 | Combinations of vanadium with antidiabetics for glucose metabolism disorders | AKESIS PHARMACEUTICALS (US) | 2007-09-06 | — | — | US | disclosed |
| US-20070197425-A1 | Combinations of chromium with antidiabetics for glucose metabolism disorders | AKESIS PHARMACEUTICALS (US) | 2007-08-23 | — | — | US | disclosed |
| US-20070196512-A1 | Combinations of vanadium with antidiabetics for glucose metabolism disorders | AKESIS PHARMACEUTICALS (US) | 2007-08-23 | — | — | US | disclosed |
| US-20070161540-A1 | Combinations of chromium or vanadium with antidiabetics for glucose metabolism disorders | AKESIS PHARMACEUTICALS (US) | 2007-07-12 | — | — | US | disclosed |
| US-20070092584-A1 | Combinations of chromium with antidiabetics for glucose metabolism disorders | AKESIS PHARMACEUTICALS (US) | 2007-04-26 | — | — | US | disclosed |
| US-20060252686-A1 | Combinations of chromium or vanadium with antidiabetics for glucose metabolism disorders | AKESIS PHARMACEUTICALS, INC. (US) | 2006-11-09 | — | — | US | disclosed |
| US-20060003981-A1 | Combinations of chromium or vanadium with antidiabetics for glucose metabolism disorders | FINE STUART A | 2006-01-05 | — | — | US | disclosed |
| US-20050282794-A1 | Combinations of chromium or vanadium with antidiabetics for glucose metabolism disorders | FINE STUART A | 2005-12-22 | — | — | US | disclosed |
| US-20050233946-A1 | Combinations of chromium or vanadium with antidiabetics for glucose metabolism disorders | FINE STUART A | 2005-10-20 | — | — | US | disclosed |
| US-20050233947-A1 | Combinations of chromium or vanadium with antidiabetics | FINE STUART A | 2005-10-20 | — | — | US | disclosed |
| US-20050187144-A1 | Combinations of chromium or vanadium with antidiabetics for glucose metabolism disorders | FINE STUART A (US) | 2005-08-25 | — | — | US | disclosed |
| US-6852760-B1 | Compositions and methods for treatment for glucose metabolism disorders | AKESIS PHARMACEUTICALS, INC. (US) | 2005-02-08 | — | — | US | disclosed |
| EP-1113804-A2 | COMBINATIONS OF CHROMIUM OR VANADIUM WITH ANTIDIABETICS FOR GLUCOSE METABOLISM DISORDERS | Akesis Pharmaceuticals, Inc. (US) | 2001-07-11 | — | — | EP | disclosed |
| WO-2001003700-A1 | COMBINATION OF CHROMIUM AND VANADIUM FOR GLUCOSE METABOLISM DISORDERS | AKESIS PHARMACEUTICALS, INC. (US) | 2001-01-18 | — | — | WO | disclosed |
| WO-2000057729-A2 | BEVERAGES FOR TREATMENT OF GLUCOSE METABOLISM DISORDERS | AKESIS PHARMACEUTICALS, INC. (US) | 2000-10-05 | — | — | WO | disclosed |
| WO-2000015211-A2 | COMPOSITIONS OF CHROMIUM OR VANADIUM WITH ANTIDIABETICS FOR GLUCOSE METABOLISM DISORDERS | AKESIS PHARMACEUTICALS, INC. (US) | 2000-03-23 | — | — | WO | disclosed |