Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 10/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | PRKDC | P78527 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | TLR2 | O60603 | 1/20 | 0.44 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.44 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10501311 | 1.00 | ERN1 (0.57) | ERN1ALDH1A1MAPTKDM4ECYP3A4 | |
| Potassium Ion SCHEMBL10501328 | 0.98 | ERN1 (0.55) | ERN1ALDH1A1MAPTKDM4ECYP3A4 | |
| SCHEMBL10501123 | 0.93 | ERN1 (0.50) | ERN1ALDH1A1MAPTKDM4ECYP3A4 | |
| Potassium Ion SCHEMBL10501133 | 0.92 | ERN1 (0.49) | ERN1ALDH1A1MAPTKDM4ECYP3A4 | |
| SCHEMBL3212120 | 0.87 | ERN1 (0.49) | ERN1ALDH1A1MAPTKDM4ECYP3A4 | |
| SCHEMBL7411310 | 0.87 | ERN1 (0.45) | ERN1ALDH1A1MAPTTDP1HPGD | |
| SCHEMBL10645648 | 0.83 | ALDH1A1 (0.51) | ALDH1A1MAPTKDM4ECYP3A4ALOX15 | |
| SCHEMBL9315238 | 0.83 | MAPT (0.43) | ERN1ALDH1A1MAPTKDM4ETDP1 | |
| SCHEMBL1318577 | 0.82 | ALDH1A1 (0.50) | ALDH1A1MAPTKDM4ECYP3A4ALOX15 | |
| SCHEMBL68284 | 0.81 | TDP1 (0.53) | ERN1ALDH1A1MAPTKDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7718598-B1 | Auxiliary for amide bond formation | THE UNIVERSITY OF QUEENSLAND (AU) | 2010-05-18 | — | — | US | disclosed |
| US-20080039625-A1 | Screening Methods | LAUTENS MARK | 2008-02-14 | — | — | US | disclosed |
| US-20080039625-A1 | Screening Methods | LAUTENS MARK | 2008-02-14 | — | — | US | disclosed |
| US-20080039625-A1 | Screening Methods | LAUTENS MARK | 2008-02-14 | — | — | US | disclosed |
| EP-1817283-A1 | 2-SUBSTITUTED INDOLES, THEIR PRECURSORS AND NOVEL PROCESSES FOR THE PREPARATION THEREOF | Lautens, Mark (CA) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006047888-A1 | 2-SUBSTITUTED INDOLES, THEIR PRECURSORS AND NOVEL PROCESSES FOR THE PREPARATION THEREOF | LAUTENS MARK (CA) | 2006-05-11 | — | — | WO | disclosed |
| EP-0220786-B1 | SUBSTITUTED QUINAZOLINONES | ORTHO PHARMA CORP (US) | 1990-11-22 | — | — | EP | disclosed |
| EP-0107398-B1 | ORTHO SUBSTITUTED DIHYDROXY-2(1H)QUINAZOLINONE-1-ALKANOIC ACIDS | ORTHO PHARMA CORP (US) | 1988-06-08 | — | — | EP | disclosed |
| EP-0227450-A2 | Substituted 5,6-Dialkoxyquinazoline Derivatives | ORTHO PHARMACEUTICAL CORPORATION (US) | 1987-07-01 | — | — | EP | disclosed |
| US-4672116-A | CARDIOTONIC AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1987-06-09 | — | — | US | disclosed |
| EP-0220786-A2 | Substituted quinazolinones | ORTHO PHARMACEUTICAL CORPORATION (US) | 1987-05-06 | — | — | EP | disclosed |
| US-4639518-A | CARDIOTONIC AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1987-01-27 | — | — | US | disclosed |
| US-4631283-A | RENAL VASODILATORS, CARDIOVASCULAR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1986-12-23 | — | — | US | disclosed |
| EP-0176333-A2 | Substituted quinazolinediones | ORTHO PHARMACEUTICAL CORPORATION (US) | 1986-04-02 | — | — | EP | disclosed |
| US-4490374-A | CARDIOVASCULAR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1984-12-25 | — | — | US | disclosed |
| EP-0107398-A1 | Ortho substituted dihydroxy-2(1H)quinazolinone-1-alkanoic acids | ORTHO PHARMACEUTICAL CORPORATION (US) | 1984-05-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039625-A1 | Screening Methods | CBR3, ZKSCAN2, CRBN | ERN1 4455/4885ALDH1A1 2175/4885MAPT 4661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.