Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | PTAFR | P25105 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | GMNN | O75496 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL2733734 | 0.82 | SMN1; SMN2 (0.65) | SMN1; SMN2ADRA1DPTAFRHTR1DHTR2C | |
| Choline SCHEMBL6017026 | 0.81 | SMN1; SMN2 (0.63) | SMN1; SMN2MAPK1MEN1LMNAKMT2A | |
| Choline SCHEMBL16267475 | 0.78 | SMN1; SMN2 (0.64) | SMN1; SMN2ADRA1DPTAFRHTR1DHTR2C | |
| SCHEMBL245306 | 0.78 | SMN1; SMN2 (1.00) | SMN1; SMN2ADRA1DPTAFRHTR1DHTR2C | |
| SCHEMBL272506 | 0.78 | SMN1; SMN2 (1.00) | SMN1; SMN2ADRA1DPTAFRHTR1DHTR2C | |
| SCHEMBL63754 | 0.78 | SMN1; SMN2 (1.00) | SMN1; SMN2ADRA1DPTAFRHTR1DHTR2C | |
| Choline SCHEMBL29689576 | 0.77 | SMN1; SMN2 (0.59) | SMN1; SMN2ADRA1DPTAFRHTR1DHTR2C | |
| Choline SCHEMBL29876695 | 0.77 | SMN1; SMN2 (0.58) | SMN1; SMN2MEN1LMNAKMT2ACYP3A4 | |
| Choline SCHEMBL1009005 | 0.77 | SMN1; SMN2 (0.58) | SMN1; SMN2MEN1LMNAKMT2ACYP3A4 | |
| Hydrogen Peroxide SCHEMBL15769657 | 0.77 | SMN1; SMN2 (0.97) | SMN1; SMN2ADRA1DPTAFRHTR1DHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080279956-A1 | Method for collecting a live placenta cord stem cell | LIN TUNG-HO | 2008-11-13 | — | — | US | disclosed |