Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 2/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | CDC25A | P30304 | 1/20 | 0.32 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.31 |
| ▸ | GMNN | O75496 | 3/20 | 0.31 |
| ▸ | BLM | P54132 | 3/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | PRKCG | P05129 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL6017026 | 0.89 | SMN1; SMN2 (0.63) | SMN1; SMN2LMNAMEN1KMT2ACYP3A4 | |
| Choline SCHEMBL29876695 | 0.85 | SMN1; SMN2 (0.58) | SMN1; SMN2LMNAMEN1KMT2ACYP3A4 | |
| Choline SCHEMBL1009005 | 0.85 | SMN1; SMN2 (0.58) | SMN1; SMN2LMNAMEN1KMT2ACYP3A4 | |
| SCHEMBL4450401 | 0.84 | SMN1; SMN2 (0.53) | SMN1; SMN2LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL124155 | 0.84 | SMN1; SMN2 (0.53) | SMN1; SMN2LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL16567918 | 0.84 | SMN1; SMN2 (0.53) | SMN1; SMN2LMNAMEN1KMT2AALDH1A1 | |
| (2E)-Hexenoic Acid SCHEMBL29002245 | 0.83 | SMN1; SMN2 (0.48) | SMN1; SMN2MEN1KMT2AS1PR1ALDH1A1 | |
| Choline SCHEMBL4889640 | 0.82 | SMN1; SMN2 (0.63) | SMN1; SMN2LMNAMEN1KMT2ACYP3A4 | |
| Choline SCHEMBL16618494 | 0.82 | SMN1; SMN2 (0.53) | SMN1; SMN2LMNAMEN1KMT2ACYP3A4 | |
| Choline SCHEMBL29033638 | 0.82 | SMN1; SMN2 (0.53) | SMN1; SMN2LMNAMEN1KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 165 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3869192-B1 | METHOD FOR QUANTITATIVE DETECTION OF VARIOUS METABOLITES IN BIOLOGICAL SAMPLE | HUMAN METABOLOMICS INST INC (CN) | 2026-05-13 | — | — | EP | claimed |
| US-20250258146-A1 | QUANTITATIVE DETECTION METHOD OF MULTIPLE METABOLITES IN BIOLOGICAL SAMPLE AND METABOLIC CHIP | HUMAN METABOLOMICS INSTITUTE INC. (CN) | 2025-08-14 | — | — | US | claimed |
| CN-117585944-A | Novel swing piece of sapphire material | 北京星箭传感器科技有限公司 | 2024-02-23 | — | — | CN | claimed |
| US-20230263736-A1 | SOFT GELATIN CAPSULES | ITF RESEARCH PHARMA, S.L.U (ES) | 2023-08-24 | — | — | US | claimed |
| EP-4171519-A1 | SOFT GELATIN CAPSULES | ITF Research Pharma, S.L.U. (ES) | 2023-05-03 | — | — | EP | claimed |
| WO-2023007088-A1 | FOOD SUPPLEMENT FOR COMBATING FEMALE AND MALE INFERTILITY | NURIBIOL (FR) | 2023-02-02 | — | — | WO | claimed |
| CN-114558061-A | Loquat leaf extract and preparation method and application thereof | 浙江大学 | 2022-05-31 | — | — | CN | claimed |
| US-20220026398-A1 | QUANTITATIVE DETECTION METHOD OF MULTIPLE METABOLITES IN BIOLOGICAL SAMPLE AND METABOLIC CHIP | HUMAN METABOLOMICS INSTITUTE INC. (CN) | 2022-01-27 | — | — | US | claimed |
| WO-2021260093-A1 | SOFT GELATIN CAPSULES | ITF RESEARCH PHARMA, S.L.U (ES) | 2021-12-30 | — | — | WO | claimed |
| CN-109709220-B | Combined marker for diagnosing bladder cancer, kit and application | 中国科学院大连化学物理研究所 | 2021-09-17 | — | — | CN | claimed |
| EP-3400267-A1 | TUNGSTEN PROCESSING SLURRY WITH CATALYST | Cabot Microelectronics Corporation (US) | 2018-11-14 | — | — | EP | claimed |
| CN-105126179-B | Sustained-release drug carrier composition | 波利皮得有限公司 | 2018-09-25 | — | — | CN | claimed |
| US-10066126-B2 | Tungsten processing slurry with catalyst | CABOT MICROELECTRONICS CORPORATION (US) | 2018-09-04 | — | — | US | claimed |
| CN-103260702-B | Sustained release formulations of non-steroidal anti-inflammatory drugs | 帕西拉制药有限公司 | 2018-07-27 | — | — | CN | claimed |
| CN-108271360-A | Lipophilic cationic dendritic polymer and use thereof | 得克萨斯州大学系统董事会 | 2018-07-10 | — | — | CN | claimed |
| CN-104971672-B | Method for preparing major diameter synthesis membrane vesicle | 帕西拉制药有限公司 | 2018-01-02 | — | — | CN | claimed |
| CN-107261110-A | The novel formulation of the liposomal encapsulated glycopeptide antibiotic of PEGylation | 健康科学西部大学 | 2017-10-20 | — | — | CN | claimed |
| CN-104959087-B | For preparing the method that major diameter synthesizes membrane vesicle | 帕西拉制药有限公司 | 2017-08-15 | — | — | CN | claimed |
| WO-2017120402-A1 | TUNGSTEN PROCESSING SLURRY WITH CATALYST | CABOT MICROELECTRONICS CORPORATION (US) | 2017-07-13 | — | — | WO | claimed |
| US-20170190936-A1 | TUNGSTEN PROCESSING SLURRY WITH CATALYST | CMC MATERIALS LLC | 2017-07-06 | — | — | US | claimed |