Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 9/20 | 0.67 |
| ▸ | SPHK1 | Q9NYA1 | 9/20 | 0.67 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4889839 | 1.00 | SPHK2 (0.67) | SPHK2SPHK1HRH3SIGMAR1 | |
| SCHEMBL8879669 | 0.85 | SPHK2 (0.67) | SPHK2SPHK1HRH3SIGMAR1 | |
| SCHEMBL15921347 | 0.85 | SPHK2 (0.71) | SPHK2SPHK1HRH3 | |
| SCHEMBL15921348 | 0.85 | SPHK2 (0.71) | SPHK2SPHK1HRH3 | |
| SCHEMBL12156622 | 0.84 | SPHK1 (0.60) | SPHK2SPHK1 | |
| SCHEMBL3197717 | 0.84 | SPHK1 (0.60) | SPHK2SPHK1 | |
| SCHEMBL3562460 | 0.84 | SPHK1 (0.60) | SPHK2SPHK1 | |
| SCHEMBL27627908 | 0.84 | SPHK2 (0.66) | SPHK2SPHK1HRH3 | |
| SCHEMBL4804878 | 0.82 | SPHK2 (0.64) | SPHK2SPHK1HRH3SIGMAR1 | |
| SCHEMBL4804888 | 0.82 | SPHK2 (0.64) | SPHK2SPHK1HRH3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080114007-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080114007-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | FLT3, FES, ALK | SPHK2 1171/4885SPHK1 982/4885HRH3 1544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.