Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 10/20 | 0.67 |
| ▸ | SPHK1 | Q9NYA1 | 10/20 | 0.67 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6797294 | 0.95 | SPHK2 (0.62) | SPHK2SPHK1TRPV6HRH3SIGMAR1 | |
| SCHEMBL6797298 | 0.95 | SPHK2 (0.62) | SPHK2SPHK1TRPV6HRH3SIGMAR1 | |
| SCHEMBL4889839 | 0.85 | SPHK2 (0.67) | SPHK2SPHK1HRH3SIGMAR1 | |
| SCHEMBL15921347 | 0.85 | SPHK2 (0.71) | SPHK2SPHK1HRH3 | |
| SCHEMBL4889834 | 0.85 | SPHK2 (0.67) | SPHK2SPHK1HRH3SIGMAR1 | |
| SCHEMBL15921348 | 0.85 | SPHK2 (0.71) | SPHK2SPHK1HRH3 | |
| SCHEMBL27627908 | 0.84 | SPHK2 (0.66) | SPHK2SPHK1HRH3 | |
| SCHEMBL4804878 | 0.82 | SPHK2 (0.64) | SPHK2SPHK1HRH3SIGMAR1 | |
| SCHEMBL4804888 | 0.82 | SPHK2 (0.64) | SPHK2SPHK1HRH3SIGMAR1 | |
| SCHEMBL4809169 | 0.81 | HRH3 (0.68) | SPHK2SPHK1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607950-A | IRRITABLE BOWEL SYNDROME | PFIZER INC. (US) | 1997-03-04 | — | — | US | disclosed |
| EP-0508988-B1 | MUSCARINIC RECEPTOR ANTAGONISTS | PFIZER LTD (GB) | 1994-03-02 | — | — | EP | disclosed |
| EP-0508988-A1 | MUSCARINIC RECEPTOR ANTAGONISTS. | PFIZER LTD (GB) | 1992-10-21 | — | — | EP | disclosed |
| WO-1991010647-A1 | MUSCARINIC RECEPTOR ANTAGONISTS | PFIZER LIMITED (GB) | 1991-07-25 | — | — | WO | disclosed |