Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
| ▸ | FGF23 | Q9GZV9 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | HNF4A | P41235 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15677707 | 0.80 | KDM4E (0.47) | ALDH1A1HPGDHSD17B10CA12CA1 | |
| SCHEMBL5074857 | 0.80 | KDM4E (0.47) | ALDH1A1HPGDHSD17B10CA12CA1 | |
| SCHEMBL5074856 | 0.80 | KDM4E (0.47) | ALDH1A1HPGDHSD17B10CA12CA1 | |
| SCHEMBL15094515 | 0.77 | ALDH1A1 (0.56) | ALDH1A1HPGDBCL2L1HSD17B10BACE1 | |
| SCHEMBL3963384 | 0.77 | ALDH1A1 (0.56) | ALDH1A1HPGDBCL2L1HSD17B10BACE1 | |
| SCHEMBL2160705 | 0.72 | GRIN2D (0.59) | ALDH1A1HPGDBCL2L1HSD17B10BACE1 | |
| SCHEMBL3323469 | 0.72 | GRIN2D (0.59) | ALDH1A1HPGDBCL2L1HSD17B10BACE1 | |
| SCHEMBL2160707 | 0.72 | GRIN2D (0.59) | ALDH1A1HPGDBCL2L1HSD17B10BACE1 | |
| SCHEMBL16538613 | 0.71 | KDM4E (0.55) | ALDH1A1HPGDHSD17B10KDM4EGFER | |
| SCHEMBL6824608 | 0.71 | TSHR (0.46) | ALDH1A1HPGDCA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230114408-A1 | METHODS OF MODULATING T-CELL ACTIVATION USING ESTROGEN RECEPTOR BETA (ERB) AGONISTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-04-13 | — | — | US | disclosed |
| WO-2021183760-A1 | METHODS OF MODULATING T-CELL ACTIVATION USING ESTROGEN RECEPTOR BETA (ERΒ) AGONISTS | OHIO STATE INNOVATION FOUNDATION (US) | 2021-09-16 | — | — | WO | disclosed |
| WO-2020160225-A1 | ESTROGEN RECEPTOR BETA (ERβ) AGONISTS FOR THE TREATMENT OF FIBROTIC CONDITIONS | OHIO STATE INNOVATION FOUNDATION (US) | 2020-08-06 | — | — | WO | disclosed |
| US-20080033049-A1 | Hydroxy-Biphenyl-Carbaldehyde Oxime Derivatives and Their Use As Estrogenic Agents | WYETH (US) | 2008-02-07 | — | — | US | disclosed |
| EP-1808429-A3 | Hydroxy-biphenyl-carbaldehyde oxime derivatives and their use as estrogenic agents | Wyeth a Corporation of the State of Delaware (US) | 2007-10-31 | — | — | EP | disclosed |
| US-7279600-B2 | Hydroxy-biphenyl-carbaldehyde oxime derivatives and their use as estrogenic agents | WYETH (US) | 2007-10-09 | — | — | US | disclosed |
| EP-1808429-A2 | Hydroxy-biphenyl-carbaldehyde oxime derivatives and their use as estrogenic agents | Wyeth a Corporation of the State of Delaware (US) | 2007-07-18 | — | — | EP | disclosed |
| CN-1784379-A | Hydroxy-biphenyl-carbaldehyde oxime derivatives and their use as estrogenic agents | WYETH CORP (US) | 2006-06-07 | — | — | CN | disclosed |
| CN-1784379-A | Hydroxy-biphenyl-carbaldehyde oxime derivatives and their use as estrogenic agents | WYETH CORP (US) | 2006-06-07 | — | — | CN | disclosed |
| EP-1620392-A2 | HYDROXY-BIPHENYL-CARBALDEHYDE OXIME DERIVATIVES AND THEIR USE AS ESTROGENIC AGENTS | Wyeth (US) | 2006-02-01 | — | — | EP | disclosed |
| US-20050020676-A1 | Hydroxy-biphenyl-carbaldehyde oxime derivatives and their use as estrogenic agents | WYETH | 2005-01-27 | — | — | US | disclosed |
| WO-2004099122-A2 | HYDROXY-BIPHENYL-CARBALDEHYDE OXIME DERIVATIVES AND THEIR USE AS ESTROGENIC AGENTS | WYETH (US) | 2004-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080033049-A1 | Hydroxy-Biphenyl-Carbaldehyde Oxime Derivatives and Their Use As Estrogenic Agents | ESR1, ESR2, ESRRB | ALDH1A1 348/4885HPGD 1800/4885BCL2L1 808/4885 |
| US-20050020676-A1 | Hydroxy-biphenyl-carbaldehyde oxime derivatives and their use as estrogenic agents | ESR1, ESR2, ESRRB | ALDH1A1 348/4885HPGD 1800/4885BCL2L1 808/4885 |
| US-20230114408-A1 | METHODS OF MODULATING T-CELL ACTIVATION USING ESTROGEN RECEPTOR BETA (ERB) AGONISTS | ESRRG, ESR2, ESRRB | ALDH1A1 2835/4885HPGD 900/4885BCL2L1 1154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.