⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4884016 | 0.70 | — | — | |
| SCHEMBL13685915 | 0.69 | — | — | |
| SCHEMBL3807099 | 0.69 | — | — | |
| SCHEMBL14702000 | 0.69 | — | — | |
| SCHEMBL2207623 | 0.67 | MAPT (0.45) | — | |
| SCHEMBL31439271 | 0.67 | ABCC1 (0.50) | — | |
| SCHEMBL31439265 | 0.67 | ABCC1 (0.50) | — | |
| SCHEMBL13055305 | 0.67 | CA12 (0.40) | — | |
| SCHEMBL14608960 | 0.67 | — | — | |
| SCHEMBL14000536 | 0.66 | CA12 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9994534-B2 | Pain-relieving compositions and uses therefor | THE UNIVERSITY OF QUEENSLAND (AU) | 2018-06-12 | — | — | US | disclosed |
| US-20180111910-A1 | PAIN-RELIEVING COMPOSITIONS AND USES THEREFOR | THE UNIVERSITY OF QUEENSLAND (AU) | 2018-04-26 | — | — | US | disclosed |
| US-20170224691-A1 | PDE INHIBITORS IN IMMUNOTHERAPY | THE JOHNS HOPKINS UNIVERSITY | 2017-08-10 | — | — | US | disclosed |
| US-9468643-B2 | PDE5 inhibitor compositions and methods for immunotherapy | THE JOHNS HOPKINS UNIVERSITY (US) | 2016-10-18 | — | — | US | disclosed |
| US-20160095836-A1 | Vector Delivery-Based Microbicides | RUSH UNIVERSITY MEDICAL CENTER (US) | 2016-04-07 | — | — | US | disclosed |
| US-20150051404-A1 | PAIN-RELIEVING COMPOSITIONS AND USES THEREFOR | THE UNIVERSITY OF QUEENSLAND (AU) | 2015-02-19 | — | — | US | disclosed |
| US-8846674-B2 | Nitric oxide enhancing prostaglandin compounds, compositions and methods of use | NICOX, S.A. (FR) | 2014-09-30 | — | — | US | disclosed |
| US-20140255433-A1 | PDE5 INHIBITOR COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY | THE JOHNS HOPKINS UNIVERSITY (US) | 2014-09-11 | — | — | US | disclosed |
| US-20130123264-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF INFLAMMATORY BOWEL DISORDERS AND INTESTINAL CANCERS | Georgia Health Sciences University | 2013-05-16 | — | — | US | disclosed |
| US-20130059844-A1 | 2-PHENYL SUBSTITUTED IMIDAZOTRIAZINONES AS PHOSPHODIESTERASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2013-03-07 | — | — | US | disclosed |
| US-20080113972-A1 | 2-Phenyl substituted imidazotriazinones as phosphodiesterase inhibitors | BAYER AKTIENGESELLSCHAFT (DE) | 2008-05-15 | — | — | US | disclosed |
| US-20080114038-A1 | Drugs Derived from Diclofenac Containing No-Donor Heterocycles, Composition and Method of Inflammation Treatment | PEDRAZZOLI JOSE | 2008-05-15 | — | — | US | disclosed |
| US-7354941-B2 | Nicotinamide benzofused-heterocyclyl derivatives useful as selective inhibitors of PDE4 isozymes | PFIZER PRODUCTS INC. (US) | 2008-04-08 | — | — | US | disclosed |
| US-7314871-B2 | 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors, for treatment of hypertension | BAYER AKTIENGESELLSCHAFT (DE) | 2008-01-01 | — | — | US | disclosed |
| WO-2007123818-A2 | ORGANIC NITRIC OXIDE ENHANCING SALTS OF PROSTAGLANDINS, COMPOSITIONS AND METHODS OF USE | NITROMED, INC. (US) | 2007-11-01 | — | — | WO | disclosed |
| WO-2007086884-A2 | ORGANIC NITRIC OXIDE DONOR SALTS OF ANTIMICROBIAL COMPOUNDS, COMPOSITIONS AND METHODS OF USE | NITROMED, INC. (US) | 2007-08-02 | — | — | WO | disclosed |
| WO-2007016095-A2 | CYCLOOXYGENASE-2 SELECTIVE INHIBITOR COMPOUNDS COMPRISING NITRIC OXIDE ENHANCING GROUPS, COMPOSITIONS AND METHODS OF USE | NITROMED, INC. (US) | 2007-02-08 | — | — | WO | disclosed |
| WO-2006042387-A1 | DRUGS DERIVED FROM DICLOFENAC CONTAINING NO-DONOR HETEROCYCLES, COMPOSITION AND METHOD OF INFLAMMATION TREATMENT | CMAX OTIMIZACÃO DE RESULTADOS S C LTDA (BR) | 2006-04-27 | — | — | WO | disclosed |
| WO-1994020478-A1 | HYDROXYMETHYL FURAZANE CARBOXYLIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT OF CARDIO-VASCULAR CONDITIONS | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-09-15 | — | — | WO | disclosed |
| US-4341898-A | DEHYDROGENATION-ISOMERIZATION REACTION IN PRESENCE OF LEWIS ACID | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1982-07-27 | — | — | US | disclosed |