Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 12/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | TACR2 | P21452 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 2/20 | 0.37 |
| ▸ | F10 | P00742 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4890414 | 0.89 | AOC3 (0.45) | AOC3SIRT1SIRT3ADRA2BSLC6A4 | |
| SCHEMBL4887678 | 0.86 | AOC3 (0.47) | AOC3SIRT1SIRT3ADRA2BSLC6A4 | |
| SCHEMBL4889728 | 0.85 | AOC3 (0.47) | AOC3SIRT1SIRT3MAOBSMN1; SMN2 | |
| SCHEMBL4886424 | 0.83 | AOC3 (0.48) | AOC3SIRT1SIRT3MAOBSMN1; SMN2 | |
| SCHEMBL5178338 | 0.82 | AOC3 (0.39) | AOC3SIRT1SIRT3ADRA2BSLC6A4 | |
| SCHEMBL4887394 | 0.81 | AOC3 (0.47) | AOC3SIRT1SIRT3MAOBSMN1; SMN2 | |
| SCHEMBL5179460 | 0.78 | AOC3 (0.57) | AOC3MAOBSMN1; SMN2KMT2ANPC1 | |
| SCHEMBL4880248 | 0.78 | AOC3 (0.57) | AOC3MAOBSMN1; SMN2KMT2ANPC1 | |
| SCHEMBL4886875 | 0.77 | AOC3 (0.59) | AOC3ADRA2BSLC6A4SLC6A3TMEM97 | |
| SCHEMBL4890415 | 0.77 | AOC3 (0.44) | AOC3SIRT1MAOBSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080015202-A1 | Thiazole Derivatives Having Vap-1 Inhibitory Activity | ASTELLAS PHARMA INC. (JP) | 2008-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015202-A1 | Thiazole Derivatives Having Vap-1 Inhibitory Activity | VCAM1, VAPB, VAPA | AOC3 163/4885SIRT1 2160/4885SIRT3 1781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.