SCHEMBL489124

SCHEMBL489124

Nc1cc(Br)ccc1S

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30470728 1.00
Hydrochloric Acid SCHEMBL10986542 0.97 KDM4E (0.39)
Hydrochloric Acid SCHEMBL9674933 0.95 KDM4E (0.38)
SCHEMBL489044 0.79
SCHEMBL29895644 0.79
SCHEMBL27518808 0.77 KDM4E (0.43)
Fluoride SCHEMBL29290721 0.77 KDM4E (0.43)
SCHEMBL5973080 0.77 KDM4E (0.43)
SCHEMBL30141068 0.75
SCHEMBL29394596 0.75

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 133 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5149755-A Aroatmic amine and halide reactants EASTMAN KODAK COMPANY (US) 1992-09-22 US claimed
US-4723010-A Process for preparing chloromethyl thiazoles or oxazoles, and intermediates for use therein PFIZER INC. (US) 1988-02-02 US claimed
US-20260078117-A1 COMPOUNDS AND METHODS OF USE TANGO THERAPEUTICS INC (US) 2026-03-19 US disclosed
WO-2025215153-A1 PRMT5 INHIBITORS Ryvu Therapeutics S.A. (PL) 2025-10-16 WO disclosed
EP-4577537-A1 SUBSTITUTED BICYCLES AS HSET INHIBITORS Merck Patent GmbH (DE) 2025-07-02 EP disclosed
CN-120091998-A Substituted bicyclic rings as HSET inhibitors 默克专利股份公司 2025-06-03 CN disclosed
US-20250171432-A1 COMPOUNDS AND METHODS OF USE TANGO THERAPEUTICS, INC. 2025-05-29 US disclosed
US-20250163048-A1 COMPOUNDS AND METHODS OF USE TANGO THERAPEUTICS, INC. 2025-05-22 US disclosed
US-12304907-B2 Compounds and methods of use TANGO THERAPEUTICS, INC. (US) 2025-05-20 US disclosed
US-12264154-B2 Compounds and methods of use TANGO THERAPEUTICS, INC. (US) 2025-04-01 US disclosed
WO-2025039979-A1 PROTEIN ARGININE METHYLTRANSFERASE-5 INHIBITOR AND PHARMACEUTICAL USE THEREOF 江苏亚虹医药科技股份有限公司 2025-02-27 WO disclosed
US-4748280-A Certain chlorination process for preparing 2-chloro-1,1,1-(C1 -C6) PFIZER INC. (US) 1988-05-31 US disclosed
US-4723010-A Process for preparing chloromethyl thiazoles or oxazoles, and intermediates for use therein PFIZER INC. (US) 1988-02-02 US disclosed
CN-86108308-A Heterocycle oxo-2 guanidine-acetic acid 1987-07-15 CN disclosed
EP-0042753-B1 NONAPEPTIDE AND DECAPEPTIDE AGONISTS OF LUTEINIZING HORMONE RELEASING HORMONE CONTAINING HETEROCYCLIC AMINO ACID RESIDUES, METHODS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOUNDS CONTAINING THEM, AND THEIR PHARMACEUTICAL USE SYNTEX (U.S.A.) INC. (US) 1984-03-21 EP disclosed
US-4375562-A Process for the preparation of bis-(amino-phenyl)-disulphides BAYER AKTIENGESELLSCHAFT (DE) 1983-03-01 US disclosed
EP-0036120-B1 PROCESS FOR THE PRODUCTION OF BIS-(AMINO-PHENYL) DISULPHIDES BAYER AG (DE) 1983-02-09 EP disclosed
US-4318905-A Nonapeptide and decapeptide agonists of luteinizing hormone releasing hormone containing heterocyclic amino acid residues SYNTEX (U.S.A.) INC. (US) 1982-03-09 US disclosed
EP-0042753-A1 Nonapeptide and decapeptide agonists of luteinizing hormone releasing hormone containing heterocyclic amino acid residues, methods for their preparation, pharmaceutical compounds containing them, and their pharmaceutical use SYNTEX (U.S.A.) INC. (US) 1981-12-30 EP disclosed
EP-0036120-A1 Process for the production of bis-(amino-phenyl) disulphides BAYER AG (DE) 1981-09-23 EP disclosed