Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 19/20 | 0.67 |
| ▸ | PRKACA | P17612 | 4/20 | 0.67 |
| ▸ | GSK3A | P49840 | 4/20 | 0.67 |
| ▸ | GSK3B | P49841 | 4/20 | 0.67 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.67 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.67 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.67 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.67 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.67 |
| ▸ | PRKX | P51817 | 2/20 | 0.67 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.67 |
| ▸ | AURKA | O14965 | 1/20 | 0.67 |
| ▸ | GRK5 | P34947 | 1/20 | 0.67 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.67 |
| ▸ | CDK8 | P49336 | 1/20 | 0.67 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.67 |
| ▸ | ROCK2 | O75116 | 15/20 | 0.59 |
| ▸ | PRKG1 | Q13976 | 4/20 | 0.56 |
| ▸ | PRKCG | P05129 | 3/20 | 0.56 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12907305 | 0.83 | ROCK2 (0.66) | ROCK1PRKACAGSK3AGSK3BCLK4 | |
| SCHEMBL12907307 | 0.83 | ROCK2 (0.66) | ROCK1PRKACAGSK3AGSK3BCLK4 | |
| SCHEMBL4884996 | 0.83 | ROCK1 (0.59) | ROCK1PRKACAGSK3AGSK3BCLK4 | |
| SCHEMBL4889181 | 0.83 | ROCK1 (0.59) | ROCK1PRKACAGSK3AGSK3BCLK4 | |
| SCHEMBL4899126 | 0.82 | ROCK2 (0.60) | ROCK1PRKACAGSK3AGSK3BCLK4 | |
| SCHEMBL4923395 | 0.81 | ROCK1 (1.00) | ROCK1PRKACAGSK3AGSK3BCLK4 | |
| SCHEMBL4929608 | 0.81 | ROCK1 (1.00) | ROCK1PRKACAGSK3AGSK3BCLK4 | |
| SCHEMBL4888782 | 0.81 | ROCK1 (0.57) | ROCK1PRKACAGSK3AGSK3BCLK4 | |
| SCHEMBL4894366 | 0.80 | ROCK1 (0.56) | ROCK1PRKACAGSK3AGSK3BCLK4 | |
| SCHEMBL4137873 | 0.78 | SMN1; SMN2 (0.57) | ROCK1ROCK2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815924-B2 | Heterocyclic carbonyl compounds | MERCK PATENT GMBH (DE) | 2014-08-26 | — | — | US | claimed |
| US-20080090882-A1 | Inhibitors of kinase h-sgk (human serum and glucocorticoid dependent kinase or SGK); diabetes, obesity, metabolic syndrome, systemic and pulmonary hypertonia, cardiovascular diseases and kidney diseases, fibroses and inflammatory processes; amide-substituted imidazoles, oxazoles, thiazoles, or furans | MERCK PATENT GMBH (DE) | 2008-04-17 | — | — | US | claimed |
| US-8815924-B2 | Heterocyclic carbonyl compounds | MERCK PATENT GMBH (DE) | 2014-08-26 | — | — | US | disclosed |
| US-20080090882-A1 | Inhibitors of kinase h-sgk (human serum and glucocorticoid dependent kinase or SGK); diabetes, obesity, metabolic syndrome, systemic and pulmonary hypertonia, cardiovascular diseases and kidney diseases, fibroses and inflammatory processes; amide-substituted imidazoles, oxazoles, thiazoles, or furans | MERCK PATENT GMBH (DE) | 2008-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080090882-A1 | Inhibitors of kinase h-sgk (human serum and glucocorticoid dependent kinase or SGK); diabetes, obesity, metabolic syndrome, systemic and pulmonary hypertonia, cardiovascular diseases and kidney diseases, fibroses and inflammatory processes; amide-substituted imidazoles, oxazoles, thiazoles, or furans | SGK1, SGK2, SGK3 | ROCK1 796/4885PRKACA 718/4885GSK3A 901/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.