⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL698653 | 0.79 | TRPA1 (0.47) | — | |
| SCHEMBL9351593 | 0.76 | — | — | |
| SCHEMBL11275664 | 0.76 | — | — | |
| SCHEMBL502289 | 0.73 | — | — | |
| SCHEMBL53087 | 0.73 | — | — | |
| SCHEMBL696770 | 0.73 | — | — | |
| SCHEMBL251277 | 0.73 | — | — | |
| SCHEMBL7076504 | 0.73 | — | — | |
| Ammonia Solution, Strong SCHEMBL9054746 | 0.71 | — | — | |
| SCHEMBL17263915 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1333834-B1 | ANTIINFLAMMATION AGENTS | AMGEN INC (US) | 2008-04-23 | — | — | EP | disclosed |
| US-20070135464-A1 | Antiinflammation agents | AMGEN, INC. | 2007-06-14 | — | — | US | disclosed |
| US-7186841-B2 | (2-imidazolyl)quinolin-4-yl aldehydes; immunomodulators, antiproliferative agents; metabolic disorders | AMGEN INC. (US) | 2007-03-06 | — | — | US | disclosed |
| US-7176314-B2 | IkB kinases (IKK) enzyme inhibitors, a imidazole-5-yl-quinoline derivatives compounds | AMGEN, INC. (US) | 2007-02-13 | — | — | US | disclosed |
| EP-1333834-A4 | ANTIINFLAMMATION AGENTS | AMGEN INC (US) | 2007-01-17 | — | — | EP | disclosed |
| US-20050043330-A1 | Antiinflammation agents | AMGEN INC. (US) | 2005-02-24 | — | — | US | disclosed |
| US-6846834-B2 | Compounds contain fused carbocyclic or heterocyclic rings; modulate expression and/or function of proteins involved in inflammation, metabolism and cell proliferation | AMGEN INC. (US) | 2005-01-25 | — | — | US | disclosed |
| US-20030181472-A1 | Inflammation modulators | TULARIK INC. | 2003-09-25 | — | — | US | disclosed |
| EP-1333834-A2 | ANTIINFLAMMATION AGENTS | Tularik Inc. (US) | 2003-08-13 | — | — | EP | disclosed |
| WO-2003048152-A2 | INFLAMMATION MODULATORS | TULARIK INC. (US) | 2003-06-12 | — | — | WO | disclosed |
| US-20020161004-A1 | Antiinflammation agents | SYNTEX (U.S.A.) LLC (US) | 2002-10-31 | — | — | US | disclosed |
| WO-2002041843-A2 | ANTIINFLAMMATION AGENTS | TULARIK INC. (US) | 2002-05-30 | — | — | WO | disclosed |