Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4892317 | 0.89 | MECP2 (0.43) | SMN1; SMN2NPC1RAB9AAURKAMAPK1 | |
| SCHEMBL4899989 | 0.79 | KDM4E (0.44) | SMN1; SMN2NPC1RAB9AAURKAMAPK1 | |
| SCHEMBL15498446 | 0.79 | P4HTM (0.62) | SMN1; SMN2NPC1RAB9AHPGDSMAPK1 | |
| Methyl Nicotinate SCHEMBL5258435 | 0.77 | ALDH1A1 (0.59) | SMN1; SMN2NPC1RAB9AAURKAKDM4E | |
| SCHEMBL4899171 | 0.74 | SYK (0.43) | SMN1; SMN2NPC1RAB9AMAPK1KDM4E | |
| SCHEMBL70712 | 0.74 | MAPK1 (0.69) | NPC1RAB9AHPGDSMAPK1P4HTM | |
| SCHEMBL29651058 | 0.74 | MAPK1 (0.69) | NPC1RAB9AHPGDSMAPK1P4HTM | |
| SCHEMBL29651074 | 0.74 | MAPK1 (0.69) | NPC1RAB9AHPGDSMAPK1P4HTM | |
| SCHEMBL6093171 | 0.72 | NPC1 (0.68) | SMN1; SMN2NPC1RAB9AAURKAKDM4E | |
| SCHEMBL27193130 | 0.70 | AXL (0.47) | SMN1; SMN2NPC1RAB9AMAPK1P4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080108600-A1 | Polycyclic Pyridines as Potassium Ion Channel Modulators | ICAGEN, INC. (US) | 2008-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108600-A1 | Polycyclic Pyridines as Potassium Ion Channel Modulators | KCNJ2, KCNH2, KCNQ1 | SMN1; SMN2 3670/4885NPC1 1509/4885RAB9A 3132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.