Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Butyric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.48 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.77 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.77 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.77 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.77 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.77 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.48 |
| ▸ | PPARG | P37231 | 7/20 | 0.48 |
| ▸ | PPARD | Q03181 | 7/20 | 0.48 |
| ▸ | PPARA | Q07869 | 7/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TLR2 | O60603 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | FABP4 | P15090 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butyric Acid SCHEMBL2704275 | 0.95 | FFAR3 (0.68) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Butyric Acid SCHEMBL9835432 | 0.94 | FFAR3 (0.77) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Butyric Acid SCHEMBL8013978 | 0.94 | FFAR3 (0.87) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Butyric Acid SCHEMBL9115265 | 0.94 | FFAR3 (0.87) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Butyric Acid SCHEMBL9224594 | 0.94 | FFAR3 (0.87) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Butyric Acid SCHEMBL385002 | 0.94 | FFAR3 (0.87) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Butyric Acid SCHEMBL11852319 | 0.94 | FFAR3 (0.87) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Butyric Acid SCHEMBL8856251 | 0.94 | FFAR3 (0.87) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Butyric Acid SCHEMBL3479926 | 0.94 | FFAR3 (0.87) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Butyric Acid SCHEMBL9551882 | 0.94 | FFAR3 (0.87) | FFAR3HDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 207 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10646832-B2 | High selectivity copolyimide membranes for separations | UOP LLC | 2020-05-12 | — | — | US | claimed |
| US-20180050309-A1 | HIGH SELECTIVITY COPOLYIMIDE MEMBRANES FOR SEPARATIONS | UOP LLC | 2018-02-22 | — | — | US | claimed |
| US-9669363-B2 | High permeance membranes for gas separations | UOP LLC (US) | 2017-06-06 | — | — | US | claimed |
| US-9662616-B2 | Aromatic alkyl-substituted polyethersulfone and UV-cross-linked aromatic alkyl-substituted polyethersulfone membranes for gas sepratations | UOP LLC (US) | 2017-05-30 | — | — | US | claimed |
| US-9567436-B2 | Super high selectivity aromatic block copolyimide membranes for separations | UOP LLC (US) | 2017-02-14 | — | — | US | claimed |
| US-20160303521-A1 | HIGH PERMEANCE MEMBRANES FOR GAS SEPARATIONS | UOP LLC | 2016-10-20 | — | — | US | claimed |
| US-20160279580-A1 | AROMATIC ALKYL-SUBSTITUTED POLYETHERSULFONE AND UV-CROSS-LINKED AROMATIC ALKYL-SUBSTITUTED POLYETHERSULFONE MEMBRANES FOR GAS SEPARATIONS | UOP LLC | 2016-09-29 | — | — | US | claimed |
| WO-2016100058-A1 | SUPER HIGH SELECTIVITY AROMATIC BLOCK COPOLYIMIDE MEMBRANES FOR SEPARATIONS | UOP LLC (US) | 2016-06-23 | — | — | WO | claimed |
| US-20160177035-A1 | SUPER HIGH SELECTIVITY AROMATIC BLOCK COPOLYIMIDE MEMBRANES FOR SEPARATIONS | UOP LLC | 2016-06-23 | — | — | US | claimed |
| US-9308503-B2 | Polybenzoxazole membranes from self-cross-linkable aromatic polyimide membranes | UOP LLC (US) | 2016-04-12 | — | — | US | claimed |
| US-20100137124-A1 | High Performance Cross-Linked Polybenzoxazole and Polybenzothiazole Polymer Membranes | UOP LLC | 2010-06-03 | — | — | US | claimed |
| US-20100133192-A1 | Polymer Membranes Prepared from Aromatic Polyimide Membranes by Thermal Treating and UV Crosslinking | UOP LLC | 2010-06-03 | — | — | US | claimed |
| US-20100133187-A1 | Polybenzoxazole Polymer-Based Mixed Matrix Membranes | UOP LLC | 2010-06-03 | — | — | US | claimed |
| WO-2009067310-A1 | MIXED MATRIX MEMBRANES CONTAINING MOLECULAR SIEVES WITH THIN PLATE MORPHOLOGY | UOP LLC (US) | 2009-05-28 | — | — | WO | claimed |
| US-20090126570-A1 | Polymer Functionalized Molecular Sieve/Polymer Mixed Matrix Membranes | UOP LLC | 2009-05-21 | — | — | US | claimed |
| US-20090126567-A1 | Mixed Matrix Membranes Containing Molecular Sieves With Thin Plate Morphology | UOP LLC | 2009-05-21 | — | — | US | claimed |
| US-20090120875-A1 | High Performance Mixed Matrix Membranes Incorporating at Least Two Kinds of Molecular Sieves | UOP LLC | 2009-05-14 | — | — | US | claimed |
| US-20080295692-A1 | UV CROSS-LINKED POLYMER FUNCTIONALIZED MOLECULAR SIEVE/POLYMER MIXED MATRIX MEMBRANES FOR SULFUR REDUCTION | UOP LLC | 2008-12-04 | — | — | US | claimed |
| US-20080296527-A1 | UV CROSS-LINKED POLYMER FUNCTIONALIZED MOLECULAR SIEVE/POLYMER MIXED MATRIX MEMBRANES | UOP LLC | 2008-12-04 | — | — | US | claimed |
| US-20080142440-A1 | Liquid Separations Using High Performance Mixed Matrix Membranes | UOP LLC | 2008-06-19 | — | — | US | claimed |