Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL540381 | 0.81 | MAPT (0.45) | TSHRCYP3A4ALDH1A1RECQLMAPT | |
| SCHEMBL2596740 | 0.78 | CYP1A2 (0.46) | TSHRCYP3A4ALDH1A1RECQLMAPT | |
| SCHEMBL29671003 | 0.78 | TSHR (0.42) | TSHRCYP3A4ALDH1A1RECQLMAPT | |
| SCHEMBL624089 | 0.78 | TSHR (0.42) | TSHRCYP3A4ALDH1A1RECQLMAPT | |
| SCHEMBL4773718 | 0.76 | MAPT (0.46) | TSHRCYP3A4ALDH1A1RECQLMAPT | |
| SCHEMBL17504823 | 0.74 | TSHR (0.39) | TSHRCYP3A4ALDH1A1RECQLHSD17B10 | |
| SCHEMBL11611060 | 0.72 | ALDH1A1 (0.39) | ALDH1A1MAPTKDM4ENPC1S1PR4 | |
| SCHEMBL14015137 | 0.72 | SMN1; SMN2 (0.44) | TSHRCYP3A4ALDH1A1RECQLMAPT | |
| SCHEMBL18298485 | 0.72 | MEN1 (0.47) | ALDH1A1MAPTNPC1HTTRAB9A | |
| SCHEMBL9104563 | 0.71 | ALDH1A1 (0.48) | TSHRALDH1A1MAPTNPC1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1840122-B1 | AMINOPYRIMIDINE COMPOUNDS AND THEIR SALTS, PROCESS FOR PREPARATION AND PHARMACEUTICAL USE THEREOF | SUN PIAOYANG (CN) | 2013-08-28 | — | — | EP | disclosed |
| US-8183242-B2 | Aminopyrimidine compounds and their salts, process for preparation and pharmaceutical use thereof | Sun, Piaoyang (CN) | 2012-05-22 | — | — | US | disclosed |
| US-20080312251-A1 | Aminopyrimidine Compounds and Their Salts, Process for Preparation and Pharmaceutical Use Thereof | JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD. (CN) | 2008-12-18 | — | — | US | disclosed |
| EP-1840122-A1 | AMINOPYRIMIDINE COMPOUNDS AND THEIR SALTS, PROCESS FOR PREPARATION AND PHARMACEUTICAL USE THEREOF | Sun, Piaoyang (CN) | 2007-10-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312251-A1 | Aminopyrimidine Compounds and Their Salts, Process for Preparation and Pharmaceutical Use Thereof | DPYD, PKN2, TYMP | TSHR 3353/4885CYP3A4 831/4885ALDH1A1 2443/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.