Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 2/20 | 0.72 |
| ▸ | PTGFR | P43088 | 10/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4706114 | 0.90 | PDE4B (0.63) | PDE4BSMN1; SMN2TP53HTR1AADRA1D | |
| SCHEMBL4707707 | 0.89 | PDE4B (0.73) | PDE4BPTGFRSMN1; SMN2TP53 | |
| SCHEMBL4707900 | 0.89 | PDE4B (0.73) | PDE4BPTGFRSMN1; SMN2TP53HTR1A | |
| SCHEMBL4707452 | 0.89 | PDE4B (0.72) | PDE4BPTGFRSMN1; SMN2TP53HTR1A | |
| SCHEMBL4708773 | 0.88 | PDE4B (0.67) | PDE4BSMN1; SMN2TP53HTR1AADRA1D | |
| SCHEMBL6167638 | 0.87 | PDE4B (0.68) | PDE4BSMN1; SMN2TP53HTR1AADRA1D | |
| SCHEMBL4706593 | 0.87 | PDE4B (0.69) | PDE4BPTGFRSMN1; SMN2TP53HTR1A | |
| SCHEMBL4889251 | 0.86 | PDE4B (0.72) | PDE4BSMN1; SMN2TP53HTR1AADRA1D | |
| SCHEMBL6166894 | 0.84 | PDE4B (0.64) | PDE4BSMN1; SMN2TP53HTR1AADRA1D | |
| SCHEMBL4708318 | 0.84 | PDE4B (0.63) | PDE4BSMN1; SMN2TP53HTR1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080269235-A1 | PYRIDAZIN-3 (2H) -ONE DERIVATIVES AS PDE4 INHIBITORS | DAL PIAZ VITTORIO | 2008-10-30 | — | — | US | disclosed |
| EP-1503992-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE4 INHIBITORS | Almirall Prodesfarma, S.A. (ES) | 2005-02-09 | — | — | EP | disclosed |
| WO-2003097613-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE4 INHIBITORS | ALMIRALL PRODESFARMA SA (ES) | 2003-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269235-A1 | PYRIDAZIN-3 (2H) -ONE DERIVATIVES AS PDE4 INHIBITORS | PDE4A, PDE3A, PDE4B | PDE4B 3/4885PTGFR 169/4885CYP3A4 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.