SCHEMBL4894565

SCHEMBL4894565

Nc1ccc(C(=O)Nc2c(Cl)cc(N)cc2Cl)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.56
KMT2A Q03164 3/20 0.56
LMNA P02545 3/20 0.56
POLB P06746 2/20 0.56
PKM P14618 1/20 0.56
APEX1 P27695 1/20 0.56
TDP1 Q9NUW8 1/20 0.56
MAPT P10636 3/20 0.53
SMN1; SMN2 Q16637 3/20 0.51
NPSR1 Q6W5P4 1/20 0.51
HSD17B10 Q99714 1/20 0.51
PRMT1 Q99873 1/20 0.48
TYK2 P29597 1/20 0.47
PTGS1 P23219 2/20 0.46
JAK2 O60674 1/20 0.46
JAK1 P23458 1/20 0.46
CA12 O43570 1/20 0.45
CA1 P00915 1/20 0.45
CA2 P00918 1/20 0.45
CA9 Q16790 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL683823 0.86 MEN1 (0.68) MEN1KMT2ALMNAPOLBPKM
SCHEMBL7295317 0.85 NR1H4 (0.58) MEN1KMT2ALMNAPOLBMAPT
SCHEMBL4905569 0.82 MAPT (0.76) MEN1KMT2ALMNAPOLBPKM
SCHEMBL9894627 0.82 PTGS1 (0.51) MEN1KMT2ALMNAPOLBPKM
SCHEMBL30492552 0.80 MAPT (0.78) MEN1KMT2ALMNAPOLBPKM
SCHEMBL866785 0.80 MAPT (0.78) MEN1KMT2ALMNAPOLBPKM
SCHEMBL14972603 0.79 PKM (0.56) MEN1KMT2ALMNAPOLBPKM
SCHEMBL683708 0.76 KDM4E (0.70) MEN1KMT2ALMNAPOLBPKM
SCHEMBL684093 0.76 NPC1 (0.75) MEN1KMT2ALMNAPOLBPKM
SCHEMBL27586874 0.76 POLB (0.74) MEN1KMT2ALMNAPOLBPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110628025-B Polyimide precursor, polyimide, and material for use in production thereof 宇部兴产株式会社 2022-07-12 CN disclosed
US-9758623-B2 Polyimide precursor and polyimide UBE INDUSTRIES, LTD. (JP) 2017-09-12 US disclosed
US-20160032056-A1 POLYIMIDE PRECURSOR AND POLYIMIDE UBE CORPORATION (JP) 2016-02-04 US disclosed
US-20140066571-A1 POLYIMIDE PRECURSOR AND POLYIMIDE UBE INDUSTRIES, LTD. (JP) 2014-03-06 US disclosed
US-20130178597-A1 POLYIMIDE PRECURSOR, POLYIMIDE, AND MATERIALS TO BE USED IN PRODUCING SAME UBE INDUSTRIES, LTD. (JP) 2013-07-11 US disclosed
EP-2597111-A1 POLYIMIDE PRECURSOR, POLYIMIDE, AND MATERIALS TO BE USED IN PRODUCING SAME Ube Industries, Ltd. (JP) 2013-05-29 EP disclosed
US-20080119643-A1 4,4'-Diazobenzanilide Dyestuffs LENNARTZ MICHAEL 2008-05-22 US disclosed
US-4296028-A Pyrazolonyl substituted disazo pigments BASF ITALIA SPA (IT) 1981-10-20 US disclosed
US-4269769-A Diazo compounds obtained by coupling acetoacetanilides with tetrazotized diaminobenzanilides AZIENDE COLORI NAZIONALI AFFINI ACNA S.P.A. (IT) 1981-05-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080119643-A1 4,4'-Diazobenzanilide Dyestuffs CYP4B1, TYR, DDT MEN1 3273/4885KMT2A 392/4885LMNA 2986/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.