Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | CNR1 | P21554 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.45 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.45 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.45 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2684787 | 0.81 | HDAC1 (0.56) | MAPTKMT2AHTTNPSR1MEN1 | |
| SCHEMBL2685332 | 0.78 | HDAC1 (0.49) | MAPTKMT2AHTTNPSR1HDAC1 | |
| SCHEMBL3678030 | 0.76 | MAPT (0.77) | MAPTKMT2AHTTNPSR1RAB9A | |
| SCHEMBL2687809 | 0.71 | HDAC1 (0.56) | KMT2AMEN1HDAC1HDAC6RORC | |
| SCHEMBL5902414 | 0.71 | MAPT (0.77) | MAPTKMT2AHTTRAB9AMEN1 | |
| SCHEMBL2686100 | 0.70 | HDAC1 (0.58) | KMT2AMEN1HDAC1HDAC6ALDH1A1 | |
| SCHEMBL2684625 | 0.70 | HDAC1 (0.59) | HDAC1HDAC6RORC | |
| SCHEMBL2356413 | 0.70 | HDAC1 (0.72) | MAPTKMT2AHTTRAB9AMEN1 | |
| SCHEMBL15350108 | 0.69 | HDAC1 (0.73) | MAPTKMT2AHTTRAB9AMEN1 | |
| SCHEMBL10198474 | 0.68 | MAPT (0.77) | MAPTKMT2AHTTRAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1991226-A2 | INHIBITORS OF HISTONE DEACETYLASE | Merck & Co., Inc. (US) | 2008-11-19 | — | — | EP | disclosed |
| WO-2007100657-A2 | INHIBITORS OF HISTONE DEACETYLASE | MERCK & CO., INC. (US) | 2007-09-07 | — | — | WO | disclosed |