Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.77 |
| ▸ | HTT | P42858 | 1/20 | 0.77 |
| ▸ | RAB9A | P51151 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.66 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.64 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.64 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.64 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.64 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.64 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.64 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | MLYCD | O95822 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3061430 | 0.88 | MAPT (1.00) | MAPTHTTRAB9ATSHRLMNA | |
| Hydrochloric Acid SCHEMBL27689202 | 0.86 | MAPT (0.96) | MAPTHTTRAB9ATSHRLMNA | |
| SCHEMBL5879632 | 0.85 | MAPT (0.75) | MAPTHTTRAB9ATSHRLMNA | |
| SCHEMBL11705109 | 0.85 | TRPV1 (0.82) | MAPTHTTRAB9ATSHRLMNA | |
| SCHEMBL13356363 | 0.85 | MAPT (0.80) | MAPTHTTRAB9ATSHRLMNA | |
| SCHEMBL27671467 | 0.85 | MAPT (0.86) | MAPTHTTRAB9ATSHRLMNA | |
| Methyl Alcohol SCHEMBL4593446 | 0.84 | MAPT (0.93) | MAPTHTTRAB9ATSHRLMNA | |
| SCHEMBL6961827 | 0.84 | KDM1A (0.68) | MAPTHTTRAB9AHDAC3HDAC1 | |
| SCHEMBL3678030 | 0.83 | MAPT (0.77) | MAPTHTTRAB9ATSHRLMNA | |
| SCHEMBL1471759 | 0.83 | MAPT (0.77) | MAPTHTTRAB9ATSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1545613-B9 | AURISTATIN CONJUGATES AND THEIR USE FOR TREATING CANCER, AN AUTOIMMUNE DISEASE OR AN INFECTIOUS DISEASE | SEATTLE GENETICS INC (US) | 2012-01-25 | — | — | EP | disclosed |
| EP-1545613-B1 | AURISTATIN CONJUGATES AND THEIR USE FOR TREATING CANCER, AN AUTOIMMUNE DISEASE OR AN INFECTIOUS DISEASE | SEATTLE GENETICS INC (US) | 2011-07-20 | — | — | EP | disclosed |