Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 18/20 | 0.70 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4899329 | 0.87 | PDPK1 (0.76) | PDPK1RPS6KB1AKT1 | |
| SCHEMBL4744364 | 0.85 | PDPK1 (0.54) | PDPK1 | |
| SCHEMBL4745705 | 0.85 | PDPK1 (0.54) | PDPK1 | |
| SCHEMBL4890843 | 0.83 | PDPK1 (1.00) | PDPK1RPS6KB1AKT1 | |
| SCHEMBL4888580 | 0.81 | PDPK1 (0.84) | PDPK1RPS6KB1AKT1 | |
| SCHEMBL4741553 | 0.81 | PDPK1 (1.00) | PDPK1RPS6KB1AKT1 | |
| SCHEMBL4744771 | 0.81 | PDPK1 (0.83) | PDPK1 | |
| SCHEMBL4744460 | 0.78 | PDPK1 (0.80) | PDPK1 | |
| SCHEMBL4741555 | 0.75 | PDPK1 (0.73) | PDPK1RPS6KB1AKT1 | |
| SCHEMBL29644973 | 0.75 | PDPK1 (1.00) | PDPK1RPS6KB1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293712-A1 | Benzo[C][2,7]Naphtyridine Derivatives, Methods of Making Thereof and Methods of Use Thereof | WYETH (US) | 2008-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293712-A1 | Benzo[C][2,7]Naphtyridine Derivatives, Methods of Making Thereof and Methods of Use Thereof | PDPK1, PDK2, PDK3 | PDPK1 1/4885ADORA2A 1120/4885ADORA1 1872/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.