Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | F9 | P00740 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 2/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL201932 | 0.85 | NPC1 (0.43) | NPC1RAB9APIK3CDPIK3CAPIK3CB | |
| SCHEMBL2316778 | 0.84 | NPC1 (0.59) | NPC1RAB9AF9F10HDAC6 | |
| SCHEMBL4759096 | 0.78 | NPC1 (0.59) | NPC1RAB9AF9F10SYK | |
| SCHEMBL2704597 | 0.78 | NPC1 (0.48) | NPC1RAB9AF9F10HDAC6 | |
| SCHEMBL202904 | 0.77 | NPC1 (0.45) | NPC1RAB9APIK3CDPIK3CAPIK3CB | |
| SCHEMBL201165 | 0.77 | NPC1 (0.44) | NPC1RAB9AF9F10HDAC6 | |
| SCHEMBL2707226 | 0.76 | EPHX2 (0.44) | NPC1RAB9AHDAC6 | |
| SCHEMBL4567016 | 0.75 | RAB9A (0.43) | NPC1RAB9AF9F10ROCK2 | |
| SCHEMBL2706609 | 0.75 | NPC1 (0.43) | NPC1RAB9AF9F10ROCK2 | |
| SCHEMBL4567017 | 0.74 | NPC1 (0.42) | NPC1RAB9AF9F10HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996180-A1 | ANTIBACTERIAL AGENTS | Prolysis Limited (GB) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007107758-A1 | ANTIBACTERIAL AGENTS | PROLYSIS LTD (GB) | 2007-09-27 | — | — | WO | disclosed |