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SCHEMBL4895897

SCHEMBL4895897

COC(=O)c1cc(S(=O)(=O)NCCc2nc(-c3ccc(C(C)(C)C)cc3)sc2C)ccc1C(C)C

nearest known ligand 0.43

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ TP53 P04637 4/20 0.43
▸ MAPT P10636 7/20 0.41
▸ ALDH1A1 P00352 6/20 0.41
▸ KMT2A Q03164 3/20 0.41
▸ SMN1; SMN2 Q16637 2/20 0.41
▸ KDM4E B2RXH2 2/20 0.41
▸ MEN1 O00255 2/20 0.41
▸ HPGD P15428 1/20 0.41
▸ LMNA P02545 7/20 0.39
▸ HTT P42858 3/20 0.39
▸ THRB P10828 1/20 0.38
▸ NR1I2 O75469 1/20 0.38
▸ POLB P06746 1/20 0.36
▸ GAA P10253 1/20 0.36
▸ GRIA4 P48058 1/20 0.35
▸ PPARG P37231 1/20 0.35
▸ PPARA Q07869 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4903079 0.93 MAPT (0.42) TP53MAPTALDH1A1KMT2ASMN1; SMN2
SCHEMBL4906194 0.92 MAPT (0.42) TP53MAPTALDH1A1KMT2ASMN1; SMN2
SCHEMBL4903730 0.92 TP53 (0.45) TP53MAPTALDH1A1KMT2AKDM4E
SCHEMBL4906242 0.91 LMNA (0.42) TP53MAPTALDH1A1KMT2ASMN1; SMN2
SCHEMBL4905731 0.90 TP53 (0.44) TP53MAPTLMNATHRBPPARG
SCHEMBL4905623 0.90 MAPT (0.47) TP53MAPTALDH1A1LMNATHRB
SCHEMBL4903907 0.89 PPARG (0.45) TP53MAPTALDH1A1SMN1; SMN2KDM4E
SCHEMBL4906164 0.88 LMNA (0.40) TP53MAPTALDH1A1KMT2ASMN1; SMN2
SCHEMBL4895165 0.86 LMNA (0.40) TP53MAPTALDH1A1KMT2ASMN1; SMN2
SCHEMBL4894596 0.85 MAPT (0.43) TP53MAPTKDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds HAMANAKA ERNEST S 2006-10-12 — — US disclosed
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PFIZER INC 2005-12-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds PPARA, PPARG, PPARD TP53 3260/4885MAPT 1858/4885ALDH1A1 2664/4885
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PPARA, PPARG, PPARD TP53 3421/4885MAPT 1786/4885ALDH1A1 2956/4885
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PPARA, PPARG, PPARD TP53 3421/4885MAPT 1786/4885ALDH1A1 2956/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.