Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | MITF | O75030 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MECP2 | P51608 | 1/20 | 0.45 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.45 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.45 |
| ▸ | MBD2 | Q9UBB5 | 1/20 | 0.45 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | BCR | P11274 | 1/20 | 0.44 |
| ▸ | PRKCA | P17252 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14213076 | 0.86 | MECP2 (0.45) | KDM4EMAPTLMNAALDH1A1NPC1 | |
| SCHEMBL4892092 | 0.83 | MAPT (0.55) | KDM4EMAPTLMNAALDH1A1NPC1 | |
| SCHEMBL29695546 | 0.81 | NPC1 (0.62) | KDM4EMAPTLMNAALDH1A1NPC1 | |
| SCHEMBL6804094 | 0.80 | MAPT (0.60) | KDM4EMAPTLMNAALDH1A1NPC1 | |
| SCHEMBL4900015 | 0.76 | MECP2 (0.50) | KDM4ELMNAALDH1A1NPC1RAB9A | |
| SCHEMBL14182367 | 0.76 | MECP2 (0.50) | KDM4EMAPTLMNAALDH1A1NPC1 | |
| SCHEMBL4900438 | 0.74 | MEN1 (0.57) | KDM4EMAPTLMNAALDH1A1NPC1 | |
| SCHEMBL11845660 | 0.73 | MAPT (0.52) | KDM4EMAPTLMNAALDH1A1NPC1 | |
| Hydrochloric Acid SCHEMBL4902758 | 0.73 | SMN1; SMN2 (0.61) | KDM4EMAPTLMNAALDH1A1NPC1 | |
| SCHEMBL4901928 | 0.72 | MEN1 (0.48) | KDM4EMAPTLMNAALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080108600-A1 | Polycyclic Pyridines as Potassium Ion Channel Modulators | ICAGEN, INC. (US) | 2008-05-08 | — | — | US | disclosed |
| US-20080108600-A1 | Polycyclic Pyridines as Potassium Ion Channel Modulators | ICAGEN, INC. (US) | 2008-05-08 | — | — | US | disclosed |
| EP-1737852-A2 | POLYCYCLIC PYRIDINES AS POTASSIUM ION CHANNEL MODULATORS | Icagen, Inc. (US) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005100349-A2 | POLYCYCLIC PYRIDINES AS POTASSIUM ION CHANNEL MODULATORS | ICAGEN, INC. (US) | 2005-10-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108600-A1 | Polycyclic Pyridines as Potassium Ion Channel Modulators | KCNJ2, KCNH2, KCNQ1 | KDM4E 542/4885MAPT 2710/4885LMNA 3338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.