Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 11/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.42 |
| ▸ | CHUK | O15111 | 4/20 | 0.39 |
| ▸ | EPHA3 | P29320 | 3/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4903131 | 0.89 | IKBKB (0.55) | IKBKBKDM4EKMT2ACHRM4CHUK | |
| SCHEMBL4903113 | 0.82 | IKBKB (0.52) | IKBKBKDM4EKMT2APOLBCHUK | |
| SCHEMBL4903115 | 0.73 | IKBKB (0.60) | IKBKBCHUKEPHA3PDGFRANTRK1 | |
| SCHEMBL4903314 | 0.73 | IKBKB (0.62) | IKBKBCHUKEPHA3PDGFRANTRK1 | |
| SCHEMBL4896815 | 0.73 | IKBKB (0.47) | IKBKBCHUKEPHA3PDGFRANTRK1 | |
| SCHEMBL4657089 | 0.72 | IKBKB (0.92) | IKBKBCHUKEPHA3PDGFRANTRK1 | |
| SCHEMBL4892342 | 0.72 | IKBKB (0.61) | IKBKBCHUKEPHA3PDGFRANTRK1 | |
| SCHEMBL4903028 | 0.70 | IKBKB (0.56) | IKBKBCHUKEPHA3PDGFRANTRK1 | |
| SCHEMBL4903139 | 0.70 | IKBKB (0.43) | IKBKBCHUKEPHA3PDGFRANTRK1 | |
| SCHEMBL4895369 | 0.68 | IKBKB (0.66) | IKBKBCHUKEPHA3PDGFRANTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080008720-A1 | Substituted Tricyclic Heterocycles and their Uses | CYWIN CHARLES L | 2008-01-10 | — | — | US | disclosed |
| US-20080008720-A1 | Substituted Tricyclic Heterocycles and their Uses | CYWIN CHARLES L | 2008-01-10 | — | — | US | disclosed |
| US-20080008720-A1 | Substituted Tricyclic Heterocycles and their Uses | CYWIN CHARLES L | 2008-01-10 | — | — | US | disclosed |
| US-7291733-B2 | Substituted tricyclic heterocycles and their uses | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2007-11-06 | — | — | US | disclosed |
| US-7291733-B2 | Substituted tricyclic heterocycles and their uses | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2007-11-06 | — | — | US | disclosed |
| US-7291733-B2 | Substituted tricyclic heterocycles and their uses | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2007-11-06 | — | — | US | disclosed |
| US-20050101601-A1 | Substituted tricyclic heterocycles and their uses | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050101601-A1 | Substituted tricyclic heterocycles and their uses | LTC4S, NQO1, CBR3 | IKBKB 178/4885KDM4E 3715/4885KMT2A 4239/4885 |
| US-20080008720-A1 | Substituted Tricyclic Heterocycles and their Uses | LTC4S, NQO1, CBR3 | IKBKB 178/4885KDM4E 3715/4885KMT2A 4239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.