LTC4S — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL236586	1.00	20/20
SCHEMBL238617	1.00	20/20
SCHEMBL239585	1.00	20/20
SCHEMBL240493	1.00	20/20
SCHEMBL237333	0.86	20/20
SCHEMBL239705	0.85	20/20
SCHEMBL236661	0.82	20/20
SCHEMBL238311	0.82	20/20
SCHEMBL239217	0.82	20/20
SCHEMBL237336	0.80	20/20
SCHEMBL252866	0.80	20/20
SCHEMBL238423	0.79	20/20
SCHEMBL252766	0.79	20/20
SCHEMBL238453	0.79	20/20
SCHEMBL237285	0.79	20/20
SCHEMBL239808	0.78	20/20
SCHEMBL240442	0.78	20/20
SCHEMBL253462	0.78	20/20
SCHEMBL236678	0.77	20/20
SCHEMBL238788	0.77	20/20

Clinical trials — most relevant to LTC4S by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Open-label Study of the Effects of Montelukast in Patients With Chronic Cough	PHASE4	COMPLETED
TEAM (Trial on Efficacy and Quality of Life Among Asthmatic Patient With Montelukast)	PHASE4	COMPLETED
Predicting Response to Standardized Pediatric Colitis Therapy	PHASE4	COMPLETED
Investigation to Identify Predictors of Response to a Treatment With Montelukast	PHASE4	COMPLETED
Montelukast in Parkinson Disease	PHASE2/PHASE3	RECRUITING
Predicting the Response to Montelukast by Genetic Variation in Asthmatics	PHASE3	COMPLETED
Ramatroban/Montelukast Versus Montelukast/Placebo on the Early Allergic Reaction in Asthma Sensitive to House Dust Mite	PHASE2/PHASE3	WITHDRAWN
Montelukast for Early Life Wheezing	PHASE2/PHASE3	COMPLETED
Aspirin for Uncontrolled Asthma	PHASE3	COMPLETED
Serum Intercellular Adhesion Molecule -1 in Acne Vulgaris Patients : Effect of Montelukast	PHASE3	UNKNOWN
GSK2190915 Neutrophilic Asthma Study	PHASE2	COMPLETED
Treatment of Bronchial Asthma With Borage and Echium Seed Oils	PHASE1/PHASE2	COMPLETED
Investigation the Effect of Montelukast in COVID-19	PHASE2	UNKNOWN
Treating Exacerbations of Asthma With Oral Montelukast in Children	PHASE2	COMPLETED
A Single Dose Study to Assess the Regional Absorption and Bioavailability of 100mg GSK2190915A	PHASE1	COMPLETED
GSK2190915A - Bioavailability Study	PHASE1	COMPLETED
Acute Pseudophakic Cystoid Macular Edema Treatment Trial: Intravitreal Ranibizumab Versus Triamcinolone Acetonide	PHASE1	COMPLETED
A Repeat Dose Study to Investigate the Interaction of GSK2190915 on the Pharmacokinetics of Rosuvastatin	PHASE1	COMPLETED
MOntelukast as a Potential CHondroprotective Treatment Following Anterior Cruciate Ligament Reconstruction (MOCHA Trial)	EARLY_PHASE1	RECRUITING
Leukotrienes Pathway in Chinese Children With Sleep-disordered Breathing	nan	UNKNOWN
The Effectiveness of Montelukast on Atopic Dermatitis in Koreans	nan	COMPLETED
Gender Differences and SNPs in Asthmatic Patients	nan	UNKNOWN
Eicosanoid Lipids by Airway Cells During Infection With Human Rhinoviruses	nan	COMPLETED
Effect of Montelukast on the Expression and Variation of TGF-β for Children With Mild Persistent Asthma	nan	COMPLETED
Lipidomics Screening of Celecoxib in ex Vivo Human Whole Blood Assay - Part B	nan	COMPLETED
Leukotriene Polymorphisms and Montelukast Response - Ancillary to LoDo Trial	nan	COMPLETED
The Natural History of Viral Upper Respiratory Infections in Children Aged 6 to Less Than 14 Years	nan	COMPLETED
A Mechanistic Study to Evaluate the Efficacy of Montelukast on Airway Function in Asthma	nan	UNKNOWN
Montelukast in the Treatment of Duodenal Eosinophilia	nan	COMPLETED
Modification of Allergic Immunologic Response by Leukotriene Antagonists - Ancillary to ACRN IMPACT	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a LTC4S binder may also engage these)

Protein	Name	Similarity
A6XA80	—	1.000	A6XA80 →
Q60860	—	0.997	Q60860 →
Q2NKS0	—	0.995	Q2NKS0 →
Q925U2	—	0.993	Q925U2 →
P73795	—	0.974	P73795 →
Q6PWL6	—	0.973	Q6PWL6 →
PTGES	Prostaglandin E synthase	0.970	landscape →
Q9JM51	—	0.967	Q9JM51 →
Q9I2S5	—	0.967	Q9I2S5 →
A6V701	—	0.967	A6V701 →
Q8HZJ2	—	0.966	Q8HZJ2 →
O83645	—	0.966	O83645 →
P59344	—	0.966	P59344 →
Q9RS57	—	0.965	Q9RS57 →
O30387	—	0.965	O30387 →
Q9JHF3	—	0.965	Q9JHF3 →
D3RNN6	—	0.965	D3RNN6 →
Q2NWA9	—	0.964	Q2NWA9 →
A0SYQ0	—	0.964	A0SYQ0 →
O83396	—	0.964	O83396 →
Q50864	—	0.963	Q50864 →
Q2W8K5	—	0.962	Q2W8K5 →
Q9HY61	—	0.962	Q9HY61 →
P64516	—	0.962	P64516 →
P64515	—	0.962	P64515 →
P42513	—	0.962	P42513 →
P94139	—	0.962	P94139 →
A4SQX1	—	0.961	A4SQX1 →
Q95L14	—	0.961	Q95L14 →
Q4KBY6	—	0.961	Q4KBY6 →