Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 4/20 | 0.65 |
| ▸ | USP28 | Q96RU2 | 3/20 | 0.60 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | USP2 | O75604 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | CASP7 | P55210 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | SYK | P43405 | 1/20 | 0.53 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4898520 | 0.88 | USP28 (0.72) | CHRM4USP28USP25LMNAKMT2A | |
| SCHEMBL4893185 | 0.85 | USP28 (0.62) | CHRM4USP28USP25LMNAKMT2A | |
| SCHEMBL27708047 | 0.84 | USP28 (0.61) | CHRM4USP28USP25LMNAKMT2A | |
| SCHEMBL4897949 | 0.84 | CHRM4 (0.64) | CHRM4USP28USP25LMNAKMT2A | |
| SCHEMBL4897966 | 0.84 | USP28 (0.70) | CHRM4USP28USP25LMNAKMT2A | |
| SCHEMBL4895200 | 0.84 | USP28 (0.65) | CHRM4USP28USP25LMNAKMT2A | |
| SCHEMBL4888275 | 0.83 | USP28 (0.74) | CHRM4USP28USP25LMNAKMT2A | |
| SCHEMBL4887038 | 0.83 | USP28 (0.67) | CHRM4USP28USP25LMNAKMT2A | |
| SCHEMBL4898201 | 0.83 | KMT2A (0.59) | CHRM4USP28USP25LMNAKMT2A | |
| SCHEMBL4890911 | 0.83 | USP28 (0.66) | CHRM4USP28USP25LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080306107-A1 | Compounds | ASTRAZENECA AB (SE) | 2008-12-11 | — | — | US | claimed |
| CN-101128470-A | Novel compounds | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | claimed |
| EP-1833834-A1 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2007-09-19 | — | — | EP | claimed |
| WO-2006068618-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | WO | claimed |
| US-20080306107-A1 | Compounds | ASTRAZENECA AB (SE) | 2008-12-11 | — | — | US | disclosed |
| CN-101128470-A | Novel compounds | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | disclosed |
| EP-1833834-A1 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006068618-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306107-A1 | Compounds | FURIN, PCSK9, SLC10A1 | CHRM4 942/4885USP28 4875/4885USP25 4874/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.