Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 2/20 | 0.61 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.61 |
| ▸ | FER | P16591 | 2/20 | 0.61 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.61 |
| ▸ | LTK | P29376 | 1/20 | 0.61 |
| ▸ | CDK8 | P49336 | 1/20 | 0.61 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.61 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.49 |
| ▸ | ROS1 | P08922 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 6/20 | 0.46 |
| ▸ | CDK2 | P24941 | 5/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.46 |
| ▸ | CDC7 | O00311 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.46 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11485594 | 0.84 | LRRK2 (0.73) | ACVR1LRRK2FERPDGFRALTK | |
| SCHEMBL11753364 | 0.79 | CHEK1 (0.47) | ACVR1LRRK2FERPDGFRALTK | |
| SCHEMBL11744445 | 0.79 | LRRK2 (0.40) | ACVR1LRRK2FERPDGFRALTK | |
| SCHEMBL11751390 | 0.79 | CSNK1G1 (0.62) | ACVR1LRRK2FERPDGFRALTK | |
| SCHEMBL11634099 | 0.79 | CHEK1 (0.62) | ACVR1LRRK2FERPDGFRALTK | |
| SCHEMBL11529475 | 0.79 | CHEK1 (0.62) | ACVR1LRRK2FERPDGFRALTK | |
| SCHEMBL11535564 | 0.79 | LRRK2 (0.40) | ACVR1LRRK2FERPDGFRALTK | |
| SCHEMBL11557784 | 0.79 | CHEK1 (0.47) | ACVR1LRRK2FERPDGFRALTK | |
| SCHEMBL11748758 | 0.79 | CHEK1 (0.47) | ACVR1LRRK2FERPDGFRALTK | |
| SCHEMBL11745945 | 0.78 | CHEK1 (0.45) | ACVR1LRRK2FERPDGFRALTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5001122-A | Use of diazepinones for treating disorders of the microcirculation | DR. KARL THOMAE GMBH (DE) | 1991-03-19 | — | — | US | claimed |
| US-20080275023-A1 | N-Hydroxyamides Omege-Substituted with Tricyclic Groups as Histone Deacetylase Inhibitors, Their Preparation and Use in Pharmaceutical Formulations | MENARIN INTERNATIONAL OPERATIONS LUXEMBOURG S.A. (LU) | 2008-11-06 | — | — | US | disclosed |
| EP-1863776-A1 | N-HYDROXYAMIDES OMEGA-SUBSTITUTED WITH TRICYCLIC GROUPS AS HISTONE DEACETYLASE INHIBITORS, THEIR PREPARATION AND USE IN PHARMACEUTICAL FORMULATIONS | Menarini International Operations Luxembourg S.A. (LU) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006097449-A1 | N-HYDROXYAMIDES OMEGA-SUBSTITUTED WITH TRICYCLIC GROUPS AS HISTONE DEACETYLASE INHIBITORS, THEIR PREPARATION AND USE IN PHARMACEUTICAL FORMULATIONS | MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A. (LU) | 2006-09-21 | — | — | WO | disclosed |
| US-20040063694-A1 | Compound useful for the treatment of CNS disorders | BROWDER MONTE R (US) | 2004-04-01 | — | — | US | disclosed |
| WO-1996022282-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1996-07-25 | — | — | WO | disclosed |
| US-5001122-A | Use of diazepinones for treating disorders of the microcirculation | DR. KARL THOMAE GMBH (DE) | 1991-03-19 | — | — | US | disclosed |
| EP-0342474-A2 | Use of diazepinones for the preparation of a medicament for therapy of microcirculatory disorders | Dr. Karl Thomae GmbH (DE) | 1989-11-23 | — | — | EP | disclosed |
| EP-0309422-A2 | New amidino tricycle derivatives | ISTITUTO DE ANGELI S.p.A. (IT) | 1989-03-29 | — | — | EP | disclosed |
| EP-0039519-B1 | SUBSTITUTED THIENOTRICYCLES, PROCESS FOR THEIR PREPARATION AND THERAPEUTICAL AGENTS CONTAINING THEM | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1984-05-02 | — | — | EP | disclosed |
| US-4242518-A | Thiophene compounds and their manufacture | BASF AKTIENGESELLSCHAFT (DE) | 1980-12-30 | — | — | US | disclosed |
| US-4239897-A | Thiophene compounds and their manufacture | BASF AKTIENGESELLSCHAFT (DE) | 1980-12-16 | — | — | US | disclosed |
| US-4172831-A | CENTRAL NERVOUS SYSTEM | LILLY INDUSTRIES LIMITED (GB) | 1979-10-30 | — | — | US | disclosed |
| US-4168269-A | ANALGESICS | AMERICAN CYANAMID COMPANY (US) | 1979-09-18 | — | — | US | disclosed |
| US-4115568-A | CNS ACTIVITY | LILLY INDUSTRIES LIMITED (GB) | 1978-09-19 | — | — | US | disclosed |
| US-4115574-A | CNS ACTIVITY | LILLY INDUSTRIES LIMITED (GB) | 1978-09-19 | — | — | US | disclosed |
| US-4087421-A | NEUROLEPTIC, ANTI-DEPRESSANT AND ANALGESTIC ACTIVITY | AMERICAN CYANAMID COMPANY (US) | 1978-05-02 | — | — | US | disclosed |
| US-4007272-A | Substituted benzodiazepin-10-ones in treating pain and depression | AMERICAN CYANAMID COMPANY (US) | 1977-02-08 | — | — | US | disclosed |
| US-3953430-A | ANTIDEPRESSANTS, ANALGESICS | AMERICAN CYANAMID COMPANY (US) | 1976-04-27 | — | — | US | disclosed |
| US-3951981-A | NEUROLEPTIC, ANALGESIC | AMERICAN CYANAMID COMPANY (US) | 1976-04-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063694-A1 | Compound useful for the treatment of CNS disorders | HMGCR, GRIN2C, CYP11B2 | ACVR1 3593/4885LRRK2 305/4885FER 2398/4885 |
| US-20080275023-A1 | N-Hydroxyamides Omege-Substituted with Tricyclic Groups as Histone Deacetylase Inhibitors, Their Preparation and Use in Pharmaceutical Formulations | HDAC8, HDAC2, HDAC7 | ACVR1 4567/4885LRRK2 4734/4885FER 4206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.