Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 12/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 12/20 | 0.55 |
| ▸ | PRKACA | P17612 | 2/20 | 0.48 |
| ▸ | PLK4 | O00444 | 2/20 | 0.48 |
| ▸ | MARK3 | P27448 | 2/20 | 0.48 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.48 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.48 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.48 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.48 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4897179 | 1.00 | ROCK2 (0.55) | ROCK2ROCK1PRKACAPLK4MARK3 | |
| SCHEMBL4893182 | 0.98 | ROCK2 (0.57) | ROCK2ROCK1PRKACAPLK4MARK3 | |
| SCHEMBL4893172 | 0.98 | ROCK2 (0.57) | ROCK2ROCK1PRKACAPLK4MARK3 | |
| SCHEMBL4887132 | 0.95 | ROCK2 (0.51) | ROCK2ROCK1PRKACAPLK4MARK3 | |
| SCHEMBL4887123 | 0.95 | ROCK2 (0.51) | ROCK2ROCK1PRKACAPLK4MARK3 | |
| SCHEMBL4898445 | 0.89 | ROCK2 (0.68) | ROCK2ROCK1PRKACAPLK4MARK3 | |
| SCHEMBL4895676 | 0.89 | ROCK2 (0.55) | ROCK2ROCK1PRKACAPLK4MARK3 | |
| SCHEMBL4895685 | 0.89 | ROCK2 (0.55) | ROCK2ROCK1PRKACAPLK4MARK3 | |
| SCHEMBL4898442 | 0.89 | ROCK2 (0.68) | ROCK2ROCK1PRKACAPLK4MARK3 | |
| SCHEMBL14520576 | 0.89 | ROCK2 (0.59) | ROCK2ROCK1PRKACAPLK4MARK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080064681-A1 | Therapeutic agent for treating glaucoma | D. WESTERN THERAPEUTICS INSTITUTE, INC. (JP) | 2008-03-13 | — | — | US | disclosed |
| US-20080064681-A1 | Therapeutic agent for treating glaucoma | D. WESTERN THERAPEUTICS INSTITUTE, INC. (JP) | 2008-03-13 | — | — | US | disclosed |
| US-20080064681-A1 | Therapeutic agent for treating glaucoma | D. WESTERN THERAPEUTICS INSTITUTE, INC. (JP) | 2008-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064681-A1 | Therapeutic agent for treating glaucoma | PDE6G, PDE3A, PDE5A | ROCK2 194/4885ROCK1 111/4885PRKACA 1537/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.