Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 15/20 | 0.68 |
| ▸ | BCR | P11274 | 12/20 | 0.68 |
| ▸ | ABL2 | P42684 | 2/20 | 0.66 |
| ▸ | SRC | P12931 | 9/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.62 |
| ▸ | PDGFRA | P16234 | 8/20 | 0.62 |
| ▸ | PRKCA | P17252 | 4/20 | 0.62 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.62 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.60 |
| ▸ | PRKCG | P05129 | 1/20 | 0.60 |
| ▸ | PRKCB | P05771 | 1/20 | 0.60 |
| ▸ | PRKCH | P24723 | 1/20 | 0.60 |
| ▸ | PRKCI | P41743 | 1/20 | 0.60 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.60 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.60 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.60 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.60 |
| ▸ | GSK3B | P49841 | 2/20 | 0.59 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.59 |
| ▸ | JAK3 | P52333 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4902913 | 0.92 | ABL1 (0.57) | ABL1BCRABL2SRCPDGFRB | |
| SCHEMBL4894465 | 0.89 | ABL1 (0.73) | ABL1BCRABL2SRCPDGFRB | |
| SCHEMBL4894484 | 0.88 | ABL1 (0.67) | ABL1BCRABL2SRCPDGFRB | |
| SCHEMBL8349109 | 0.87 | JAK2 (0.61) | ABL1BCRABL2SRCPRKD3 | |
| SCHEMBL4903833 | 0.86 | SYK (0.57) | ABL1BCRJAK3SYKJAK2 | |
| SCHEMBL4901605 | 0.84 | ABL1 (0.62) | ABL1BCRABL2SRCPDGFRB | |
| SCHEMBL4382875 | 0.84 | JAK2 (0.63) | ABL1BCRSRCJAK3JAK2 | |
| SCHEMBL13924584 | 0.84 | SYK (0.53) | ABL1BCRABL2SRCPRKD3 | |
| SCHEMBL14348363 | 0.83 | JAK2 (0.64) | JAK3JAK2JAK1 | |
| SCHEMBL4901373 | 0.82 | ABL1 (0.59) | ABL1BCRABL2SRCPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080187575-A1 | Pyrimidine Derivatives | VICHEM CHEMIE KFT (HU) | 2008-08-07 | — | — | US | claimed |
| EP-1786781-A2 | PYRIMIDINE DERIVATIVES | GPC Biotech AG (DE) | 2007-05-23 | — | — | EP | claimed |
| WO-2006021458-A2 | PYRIMIDINE DERIVATIVES | GPC BIOTECH AG (DE) | 2006-03-02 | — | — | WO | claimed |
| US-20080187575-A1 | Pyrimidine Derivatives | VICHEM CHEMIE KFT (HU) | 2008-08-07 | — | — | US | disclosed |
| EP-1786781-A2 | PYRIMIDINE DERIVATIVES | GPC Biotech AG (DE) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006021458-A2 | PYRIMIDINE DERIVATIVES | GPC BIOTECH AG (DE) | 2006-03-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080187575-A1 | Pyrimidine Derivatives | TYMP, TDP1, PNP | ABL1 2843/4885BCR 2315/4885ABL2 2837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.