Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.61 |
| ▸ | JAK3 | P52333 | 4/20 | 0.61 |
| ▸ | JAK1 | P23458 | 2/20 | 0.61 |
| ▸ | TYK2 | P29597 | 3/20 | 0.56 |
| ▸ | ABL1 | P00519 | 4/20 | 0.54 |
| ▸ | BCR | P11274 | 3/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.54 |
| ▸ | SRC | P12931 | 3/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.54 |
| ▸ | PRKACA | P17612 | 1/20 | 0.54 |
| ▸ | PRKACG | P22612 | 1/20 | 0.54 |
| ▸ | PRKACB | P22694 | 1/20 | 0.54 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.53 |
| ▸ | SMG1 | Q96Q15 | 4/20 | 0.51 |
| ▸ | CDK1 | P06493 | 3/20 | 0.51 |
| ▸ | CDK2 | P24941 | 3/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | ABL2 | P42684 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4382875 | 0.93 | JAK2 (0.63) | JAK2JAK3JAK1TYK2ABL1 | |
| SCHEMBL14348343 | 0.89 | ABL1 (0.54) | JAK2JAK3JAK1TYK2ABL1 | |
| SCHEMBL4897217 | 0.87 | ABL1 (0.68) | JAK2JAK3JAK1ABL1BCR | |
| SCHEMBL4902913 | 0.86 | ABL1 (0.57) | JAK2JAK3JAK1TYK2ABL1 | |
| SCHEMBL8349351 | 0.84 | JAK2 (0.58) | JAK2JAK3ABL1BCRSRC | |
| SCHEMBL4903833 | 0.83 | SYK (0.57) | JAK2JAK3JAK1ABL1BCR | |
| SCHEMBL14348362 | 0.82 | JAK2 (0.56) | JAK2JAK3ABL1BCRSRC | |
| SCHEMBL3203453 | 0.81 | ALDH1A1 (0.72) | MAP4K4ALDH1A1HTT | |
| SCHEMBL14348363 | 0.81 | JAK2 (0.64) | JAK2JAK3JAK1TYK2SMG1 | |
| SCHEMBL14348354 | 0.81 | JAK2 (0.54) | JAK2JAK3ABL1BCRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| WO-2004041789-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF JAK AND OTHER PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-05-21 | — | — | WO | disclosed |