Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.48 |
| ▸ | NEK4 | P51957 | 3/20 | 0.48 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.48 |
| ▸ | PRKG2 | Q13237 | 2/20 | 0.48 |
| ▸ | EEF2K | O00418 | 1/20 | 0.48 |
| ▸ | CLK2 | P49760 | 1/20 | 0.48 |
| ▸ | PRKX | P51817 | 1/20 | 0.48 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.48 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.48 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.48 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 12/20 | 0.45 |
| ▸ | CA2 | P00918 | 12/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4905370 | 0.90 | ROCK1 (0.46) | GSK3BROCK1CLK4NEK4PKN2 | |
| SCHEMBL4598765 | 0.89 | ROCK2 (0.43) | GSK3BROCK1CLK4NEK4PKN2 | |
| SCHEMBL4908463 | 0.88 | ROCK1 (0.45) | GSK3BROCK1CLK4NEK4PKN2 | |
| SCHEMBL4910893 | 0.87 | ROCK1 (0.47) | GSK3BROCK1CLK4NEK4PKN2 | |
| SCHEMBL4908343 | 0.85 | ROCK1 (0.46) | GSK3BROCK1CLK4NEK4PKN2 | |
| SCHEMBL4598260 | 0.85 | ROCK1 (0.47) | GSK3BROCK1CLK4NEK4PKN2 | |
| SCHEMBL14066718 | 0.85 | MAPKAPK2 (0.54) | GSK3BROCK1CLK4NEK4PKN2 | |
| SCHEMBL4908067 | 0.83 | GSK3B (0.44) | GSK3BROCK1CLK4NEK4PKN2 | |
| SCHEMBL4908588 | 0.83 | QPCT (0.48) | GSK3BROCK1CLK4NEK4PKN2 | |
| SCHEMBL4904962 | 0.82 | GSK3B (0.47) | GSK3BROCK1CLK4NEK4PKN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234266-A1 | Squaric Acid Derivatives II | MERCK PATENT GESELLSCHAFT (DE) | 2008-09-25 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234266-A1 | Squaric Acid Derivatives II | CHEK2, CHEK1, SGK3 | GSK3B 132/4885ROCK1 713/4885CLK4 133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.