Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 17/20 | 0.61 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.55 |
| ▸ | PLK1 | P53350 | 2/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.44 |
| ▸ | CSNK1G1 | Q9HCP0 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | RPS6KA1 | Q15418 | 2/20 | 0.44 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.44 |
| ▸ | PRKX | P51817 | 1/20 | 0.44 |
| ▸ | NEK4 | P51957 | 1/20 | 0.44 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4905846 | 1.00 | MAPKAPK2 (0.61) | MAPKAPK2PFKFB3PLK1MAPK14AURKB | |
| SCHEMBL4597033 | 0.79 | KDR (0.52) | MAPKAPK2PLK1AURKBROCK1PDGFRA | |
| SCHEMBL4596962 | 0.77 | MAPKAPK2 (0.61) | MAPKAPK2PLK1MAPK14AURKBROCK1 | |
| SCHEMBL4598811 | 0.77 | MAPKAPK2 (0.61) | MAPKAPK2PLK1MAPK14AURKBROCK1 | |
| SCHEMBL4914345 | 0.77 | MAPKAPK2 (0.67) | MAPKAPK2PLK1MAPK14AURKBROCK1 | |
| SCHEMBL1228998 | 0.77 | MAPKAPK2 (0.67) | MAPKAPK2PLK1MAPK14AURKBROCK1 | |
| SCHEMBL4911215 | 0.77 | MAPKAPK2 (0.67) | MAPKAPK2PLK1MAPK14AURKBROCK1 | |
| SCHEMBL4366319 | 0.76 | MAPKAPK2 (1.00) | MAPKAPK2PLK1AURKBROCK1PDGFRA | |
| SCHEMBL4915136 | 0.76 | MAPKAPK2 (0.65) | MAPKAPK2PLK1MAPK14AURKBROCK1 | |
| SCHEMBL4598348 | 0.76 | MAPKAPK2 (0.65) | MAPKAPK2PLK1MAPK14AURKBROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234266-A1 | Squaric Acid Derivatives II | MERCK PATENT GESELLSCHAFT (DE) | 2008-09-25 | — | — | US | claimed |
| US-20080234266-A1 | Squaric Acid Derivatives II | MERCK PATENT GESELLSCHAFT (DE) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234266-A1 | Squaric Acid Derivatives II | CHEK2, CHEK1, SGK3 | MAPKAPK2 346/4885PFKFB3 53/4885PLK1 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.