Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | RHEB | Q15382 | 2/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.32 |
| ▸ | GCGR | P47871 | 1/20 | 0.31 |
| ▸ | GIPR | P48546 | 1/20 | 0.31 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | CMA1 | P23946 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4898658 | 0.92 | MAPK8 (0.38) | ALDH1A1MAPK10MAPTSMN1; SMN2MAPK8 | |
| SCHEMBL4895489 | 0.89 | ALDH1A1 (0.39) | ALDH1A1MAPK10RHEBMCHR1MAPK8 | |
| SCHEMBL4898669 | 0.89 | ALDH1A1 (0.39) | ALDH1A1MAPK10RHEBMCHR1MAPK8 | |
| SCHEMBL4898625 | 0.88 | KDM4E (0.37) | ALDH1A1MAPK10RHEBMCHR1KDM4E | |
| SCHEMBL4901306 | 0.88 | ALDH1A1 (0.39) | ALDH1A1MAPK10RHEBMCHR1MAPT | |
| SCHEMBL4901698 | 0.87 | ALDH1A1 (0.38) | ALDH1A1MAPK10RHEBMCHR1MAPT | |
| SCHEMBL4889733 | 0.84 | ALDH1A1 (0.38) | ALDH1A1MAPK10RHEBMCHR1MAPT | |
| SCHEMBL4891960 | 0.84 | GCGR (0.34) | ALDH1A1MAPK10RHEBMCHR1GCGR | |
| SCHEMBL4901272 | 0.84 | KDM4E (0.35) | ALDH1A1MAPK10RHEBMAPTMEN1 | |
| SCHEMBL4898674 | 0.82 | ALDH1A1 (0.38) | ALDH1A1MAPK10RHEBMMP13PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080070867-A1 | 2-Imidazolone and 2-Imidazolidinone Heterocyclic Inhibitors of Tyrosine Phosphatases | METABASIS THERAPEUTICS, INC. (US) | 2008-03-20 | — | — | US | claimed |
| US-20080070867-A1 | 2-Imidazolone and 2-Imidazolidinone Heterocyclic Inhibitors of Tyrosine Phosphatases | METABASIS THERAPEUTICS, INC. (US) | 2008-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080070867-A1 | 2-Imidazolone and 2-Imidazolidinone Heterocyclic Inhibitors of Tyrosine Phosphatases | PPM1B, PPM1D, PTPRS | ALDH1A1 3704/4885MAPK10 656/4885RHEB 1672/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.