Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 13/20 | 0.49 |
| ▸ | CDK2 | P24941 | 13/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 10/20 | 0.49 |
| ▸ | FLT3 | P36888 | 5/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4898657 | 1.00 | KDM4E (0.51) | KDM4ENPC1ALDH1A1HPGDRAB9A | |
| SCHEMBL4899908 | 0.90 | PDGFRA (0.46) | TP53PDGFRACDK2CCNE1FLT3 | |
| SCHEMBL4899919 | 0.90 | PDGFRA (0.46) | TP53PDGFRACDK2CCNE1FLT3 | |
| SCHEMBL4898733 | 0.83 | FLT3 (0.62) | PDGFRACDK2CCNE1FLT3CDK1 | |
| SCHEMBL4898746 | 0.83 | FLT3 (0.62) | PDGFRACDK2CCNE1FLT3CDK1 | |
| SCHEMBL5891718 | 0.83 | FLT3 (0.53) | PDGFRACDK2CCNE1FLT3CDK1 | |
| SCHEMBL5891707 | 0.83 | FLT3 (0.53) | PDGFRACDK2CCNE1FLT3CDK1 | |
| SCHEMBL4891943 | 0.83 | RAB9A (0.49) | KDM4ENPC1ALDH1A1HPGDRAB9A | |
| SCHEMBL4889912 | 0.82 | MAPKAPK2 (0.55) | KDM4ENPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL4889926 | 0.82 | MAPKAPK2 (0.55) | KDM4ENPC1HPGDRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7041824-B2 | Purine derivatives, preparation method and use as medicines | AVENTIS PHARMA S.A. (FR) | 2006-05-09 | — | — | US | claimed |
| US-20040063732-A1 | Novel purine derivatives, preparation method and use as medicines | AVENTIS PHARMA S.A. (FR) | 2004-04-01 | — | — | US | claimed |
| US-20080090849-A1 | NOVEL PURINE DERIVATIVES, PREPARATION METHOD AND USE AS MEDICINES | AVENTIS PHARMA S.A. (FR) | 2008-04-17 | — | — | US | disclosed |
| US-7041824-B2 | Purine derivatives, preparation method and use as medicines | AVENTIS PHARMA S.A. (FR) | 2006-05-09 | — | — | US | disclosed |
| US-20060074095-A1 | Novel purine derivatives, preparation method and use as medicines | AVENTIS PHARMA S.A. (FR) | 2006-04-06 | — | — | US | disclosed |
| US-20040063732-A1 | Novel purine derivatives, preparation method and use as medicines | AVENTIS PHARMA S.A. (FR) | 2004-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063732-A1 | Novel purine derivatives, preparation method and use as medicines | CDK1, CDK6, PNP | KDM4E 1724/4885NPC1 1938/4885ALDH1A1 2175/4885 |
| US-20080090849-A1 | NOVEL PURINE DERIVATIVES, PREPARATION METHOD AND USE AS MEDICINES | CDK1, CDK6, PNP | KDM4E 1381/4885NPC1 2368/4885ALDH1A1 2605/4885 |
| US-20060074095-A1 | Novel purine derivatives, preparation method and use as medicines | CDK1, CDK6, PNP | KDM4E 1569/4885NPC1 2301/4885ALDH1A1 2370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.