Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 10/20 | 0.51 |
| ▸ | RBP4 | P02753 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MC5R | P33032 | 2/20 | 0.46 |
| ▸ | MC3R | P41968 | 2/20 | 0.46 |
| ▸ | AKT1 | P31749 | 2/20 | 0.46 |
| ▸ | AKT2 | P31751 | 2/20 | 0.46 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | TACR3 | P29371 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4778527 | 0.92 | MC4R (0.58) | MC4RRBP4LMNAMAPTNPSR1 | |
| SCHEMBL4772349 | 0.88 | MC4R (0.62) | MC4RMC5RMC3RAKT1AKT2 | |
| SCHEMBL4774413 | 0.85 | AKT1 (0.55) | MC4RLMNAMAPTNPSR1AKT1 | |
| SCHEMBL4794300 | 0.80 | CYP2C9 (0.48) | MC4RLMNAMAPTNPSR1MC5R | |
| SCHEMBL4773532 | 0.79 | MC4R (0.48) | MC4RLMNAMAPTNPSR1MC5R | |
| SCHEMBL4793774 | 0.79 | MC4R (0.63) | MC4RLMNAMAPTNPSR1AKT1 | |
| SCHEMBL4775603 | 0.76 | MC4R (0.59) | MC4RLMNAMAPTNPSR1AKT1 | |
| SCHEMBL4770245 | 0.74 | MC4R (0.68) | MC4RAKT1AKT2AKT3HDAC1 | |
| SCHEMBL4909061 | 0.74 | MC4R (0.68) | MC4RAKT1AKT2AKT3HDAC1 | |
| SCHEMBL4770617 | 0.74 | AKT1 (0.59) | MC4RLMNAMAPTNPSR1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080255149-A1 | Carboxyamine Compounds and Methods of Use Thereof | NOVARTIS AG | 2008-10-16 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255149-A1 | Carboxyamine Compounds and Methods of Use Thereof | HNMT, HDAC5, HDAC4 | MC4R 1782/4885RBP4 3077/4885LMNA 957/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.