SCHEMBL4899555

SCHEMBL4899555

C=C(CS)C(=O)OC1CCCCC1

nearest known ligand 0.42

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
EPHX1 P07099 2/20 0.42
CYP2C19 P33261 1/20 0.40
NAAA Q02083 2/20 0.39
HTT P42858 1/20 0.38
CYP19A1 P11511 4/20 0.36
CA12 O43570 2/20 0.35
CA1 P00915 2/20 0.35
CA2 P00918 2/20 0.35
CA9 Q16790 2/20 0.35
HDAC4 P56524 1/20 0.34
HDAC1 Q13547 1/20 0.34
GPR35 Q9HC97 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.32
MMP1 P03956 1/20 0.32
MMP9 P14780 1/20 0.32
MMP12 P39900 1/20 0.32
FABP7 O15540 1/20 0.31
FABP5 Q01469 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL530375 0.82 EPHX1 (0.43) EPHX1CYP2C19NAAAHTTCYP19A1
SCHEMBL29117755 0.81 EPHX1 (0.50) EPHX1CYP2C19NAAAHTTCYP19A1
SCHEMBL29117656 0.81 EPHX1 (0.50) EPHX1CYP2C19NAAAHTTCYP19A1
SCHEMBL1520936 0.81 EPHX1 (0.42) EPHX1CYP2C19NAAAHTTCYP19A1
SCHEMBL1131135 0.81 EPHX1 (0.50) EPHX1CYP2C19NAAAHTTCYP19A1
SCHEMBL5084314 0.80 EPHX1 (0.40) EPHX1CYP2C19NAAAHTTCYP19A1
SCHEMBL1524457 0.79 EPHX1 (0.44) EPHX1CYP2C19NAAAHTTCYP19A1
SCHEMBL17073950 0.79 CYP2C19 (0.46) EPHX1CYP2C19NAAAHTTCYP19A1
SCHEMBL481509 0.79 CYP2C19 (0.46) EPHX1CYP2C19NAAAHTTCYP19A1
SCHEMBL481711 0.79 EPHX1 (0.44) EPHX1CYP2C19NAAAHTTCYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080003288-A1 Responsive microgel and methods related thereto SUPRATEK PHARMA INC. (CA) 2008-01-03 US disclosed
US-7204997-B2 Responsive microgel and methods related thereto SUPRATEK PHARMA INC. (CA) 2007-04-17 US disclosed
EP-1478403-A1 RESPONSIVE MICROGEL AND METHODS RELATED THERETO SUPRATEK PHARMA, INC. (CA) 2004-11-24 EP disclosed
US-20030152623-A1 Responsive microgel and methods related thereto SUPRATEK PHARMA INC. (CA) 2003-08-14 US disclosed
US-20030153704-A1 Polymer-coated metal composites by dip autopolymerization BELL JAMES P (US) 2003-08-14 US disclosed
WO-2003063909-A1 RESPONSIVE MICROGEL AND METHODS RELATED THERETO SUPRATEK PHARMA INC. (US) 2003-08-07 WO disclosed
US-6555239-B1 Dipping the metal substrate in an acidic solution of 4-carboxyphenyl maleimide, and n-phenyl maleimide, 2-(methacryloyloxy)ethyl acetoacetate, methyl methacrylate or acrylonitrile for a time in the absence of other catalysts THE UNIVERSITY OF CONNECTICUT 2003-04-29 US disclosed
US-6491903-B1 NARROW MOLECULAR WEIGHT DISTRIBUTION SHELL-CORE POLYMERS HAVING HYDROPHILIC, CROSSLINKED PERMEABLE SHELLS AND HYDROPHOBIC CORES, USED FOR REDUCING BLOOD CHOLESTEROL AND BILE ACID UPTAKE IN INTERSTINES; DRUG DELIVERY WASHINGTON UNIVERSITY 2002-12-10 US disclosed
US-6451383-B2 APPLYING AN ACIDIC STARTING SOLUTION OF AN EMULSION OF CHEMICALLY DISTINCT MONOMERS TO A METAL SUBSTRATE WHICH CAN INITIATE POLYMERIZATION THE UNIVERSITY OF CONNECTICUT 2002-09-17 US disclosed
US-6383500-B1 Particles comprising amphiphilic copolymers, having a crosslinked shell domain and an interior core domain, useful for pharmaceutical and other applications WASHINGTON UNIVERSITY 2002-05-07 US disclosed
EP-1154866-A1 POLYMER-COATED METAL COMPOSITES BY DIP AUTOPOLYMERIZATION The University of Connecticut (US) 2001-11-21 EP disclosed
EP-0917495-A4 COMPOSITION AND METHOD FOR COATING METALS BY DIP AUTOPOLYMERIZATION UNIV CONNECTICUT (US) 2001-04-25 EP disclosed
WO-2000048750-A1 POLYMER-COATED METAL COMPOSITES BY DIP AUTOPOLYMERIZATION UNIVERSITY OF CONNECTICUT (US) 2000-08-24 WO disclosed
EP-0917495-A1 COMPOSITION AND METHOD FOR COATING METALS BY DIP AUTOPOLYMERIZATION THE UNIVERSITY OF CONNECTICUT (US) 1999-05-26 EP disclosed
EP-0910351-A1 PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS G.D. Searle & Co. (US) 1999-04-28 EP disclosed
EP-0907666-A1 PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS G.D. Searle & Co. (US) 1999-04-14 EP disclosed
US-5807612-A FORMING DECORATIVE OR PROTECTIVE OVERCOATING THE UNIVERSITY OF CONNECTICUT (US) 1998-09-15 US disclosed
WO-1998005436-A1 COMPOSITION AND METHOD FOR COATING METALS BY DIP AUTOPOLYMERIZATION THE UNIVERSITY OF CONNECTICUT (US) 1998-02-12 WO disclosed
WO-1997049736-A2 PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS G.D. SEARLE AND CO. (US) 1997-12-31 WO disclosed
WO-1997049387-A1 PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS G.D. SEARLE AND CO. (US) 1997-12-31 WO disclosed